AJP - Regu Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 283: R1245-R1253, 2002. First published August 15, 2002; doi:10.1152/ajpregu.00681.2001
0363-6119/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
283/5/R1245    most recent
00681.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (5)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bedu, E.
Right arrow Articles by Duchamp, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bedu, E.
Right arrow Articles by Duchamp, C.
Vol. 283, Issue 5, R1245-R1253, November 2002

Increased lipogenesis in isolated hepatocytes from cold-acclimated ducklings

E. Bedu, F. Chainier, B. Sibille, R. Meister, G. Dallevet, D. Garin, and C. Duchamp

Laboratoire de Physiologie des Régulations Energétiques, Cellulaires et Moléculaires, Centre National de la Recherche Scientifique-Université Claude Bernard Lyon 1, Unité Mixte de Recherches 5123, F-69622 Villeurbanne Cedex, France

Thermogenic endurance and development of metabolic cold adaptation in birds may critically depend on their ability to synthesize and use fatty acids (FA) as fuel substrates. Hepatic lipogenesis and the capacity to oxidize FA in thermogenic tissues were measured in cold-acclimated (CA) ducklings (Cairina moschata) showing original mechanisms of metabolic cold adaptation in the absence of brown adipose tissue, the specialized thermogenic tissue of rodents. The rate of FA synthesis from [U-14C]glucose and from [1-14C]acetate, measured in incubated hepatocytes isolated from 5-wk-old thermoneutral (TN; 25°C) or CA (4°C) fed ducklings, was higher than in other species. Hepatic de novo lipogenesis was further increased by cold acclimation with both glucose (+194%) and acetate (+111%) as precursor. Insulin slightly increased (+11-14%) hepatic lipogenesis from both precursors in CA ducklings, whereas glucagon was clearly inhibitory (-29 to -51%). Enhanced de novo lipogenesis was associated with higher (+171%) hepatocyte activity of glucose oxidation and larger capacity (+50 to +100%) of key lipogenic enzymes. The potential for FA oxidation was higher in liver (+61%) and skeletal muscle (+29 to +81%) homogenates from CA than from TN ducklings, suggesting that the higher hepatic lipogenesis may fuel oxidation in thermogenic tissues. Present data underline the high capacity to synthesize lipids from glucose in species like muscovy ducks susceptible to hepatic steatosis. Lipogenic capacity can be further increased in the cold and may represent an important step in the metabolic adaptation to cold of growing ducklings.

malic enzyme; glucose-6-phosphate-dehydrogenase; fatty acid synthase; acetyl-CoA carboxylase; glucagon; insulin; thermogenesis; fatty acid oxidation


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Raccurt, F. Baudimont, J. Tirard, B. Rey, E. Moureaux, A. Geloen, and C. Duchamp
Growing in Antarctica, a challenge for white adipose tissue development in Adelie penguin chicks (Pygoscelis adeliae)
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2008; 295(5): R1671 - R1679.
[Abstract] [Full Text] [PDF]

Home page
 Poult. Sci.Home page
H. Berradi, M. D. Bernadet, G. Guy, and N. Rideau
Expression of the Glucokinase Gene in Mule Duck Liver and Glucokinase Activities in Chicken and Mule Duck Livers
Poult. Sci., October 1, 2007; 86(10): 2216 - 2220.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
S.-H. Lee, A. Dobrzyn, P. Dobrzyn, S. M. Rahman, M. Miyazaki, and J. M. Ntambi
Lack of stearoyl-CoA desaturase 1 upregulates basal thermogenesis but causes hypothermia in a cold environment
J. Lipid Res., September 1, 2004; 45(9): 1674 - 1682.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online