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Department of Internal Medicine, College of Medicine, University of California, Irvine, California 92697-4075
The effect of electroacupuncture (EA) on
the reflex cardiovascular response induced by mechanical distension of
the stomach was studied in ventilated male Sprague-Dawley rats
anesthetized by ketamine and 
-chloralose. Repeated balloon inflation
of the stomach to produce 20 mmHg tension on the gastric wall induced a
consistent rise in mean arterial pressure, while heart rate (372 ± 22 beats/min) was unchanged. This response was reversed by
transection of the splanchnic nerves. Bilateral application of EA
(1-2 mA, 2 Hz) at Neiguan-Jianshi acupoints (pericardial meridian,
Pe 5-6) over the median nerve for 30 min significantly decreased
the pressor response from 33 ± 6 to 18 ± 4 mmHg
(n = 7, P < 0.05). This effect began
after 10 min of EA and continued for 40 min after termination of EA. EA
at Zusanli-Shangquxu acupoints (stomach meridian, St 36-37) over
the deep peroneal nerve similarly inhibited the pressor response. The
effect lasted for 10 min after EA was stopped (n = 6, P < 0.05), while EA at Guangming-Xuanzhong acupoints
(gallbladder meridian, GB 37-39) over the superficial peroneal
nerve did not inhibit the pressor response. Naloxone injected
intravenously (n = 6) immediately after termination of EA or administered by microinjection into the rostral ventrolateral medulla (rVLM) 25 min after initiation of EA (n = 6)
reversed the inhibition by EA, suggesting an opiate mechanism,
including the rVLM, was involved.
rostral ventrolateral medulla; Neiguan acupoint; Zusanli acupoint; naloxone; rats
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