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Am J Physiol Regul Integr Comp Physiol 283: R1354-R1361, 2002. First published September 5, 2002; doi:10.1152/ajpregu.00475.2002
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Vol. 283, Issue 6, R1354-R1361, December 2002

Transepithelial sulfate transport by avian renal proximal tubule epithelium in primary culture

Paul L. Dudas and J. Larry Renfro

Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut 06269

The mechanisms and control of transepithelial inorganic sulfate (Si) transport by primary cultures of chick renal proximal tubule monolayers in Ussing chambers were determined. The competitive anion, S2O32- (5 mM), reduced both unidirectional reabsorptive and secretory fluxes and net Si reabsorption with no effect on electrophysiological properties. The carbonic anhydrase (CA) inhibitor ethoxzolamide decreased net Si reabsorption ~45%. CAII protein and activity were detected in isolated chick proximal tubules by immunoblots and biochemical assay, respectively. Cortisol reduced net Si reabsorption up to ~50% in a concentration-dependent manner. Thyroid hormone increased net Si reabsorption threefold in 24 h, and parathyroid hormone (PTH) acutely stimulated net Si reabsorption ~45%. These data indicate that CA participates in avian proximal tubule active transepithelial Si reabsorption, which cortisol directly inhibits and T3 and PTH directly stimulate.

reabsorptive flux; secretory flux; carbonic anhydrase; chicken


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