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Am J Physiol Regul Integr Comp Physiol 283: R1386-R1394, 2002. First published September 5, 2002; doi:10.1152/ajpregu.00324.2002
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Vol. 283, Issue 6, R1386-R1394, December 2002

beta 2-Agonist fenoterol has greater effects on contractile function of rat skeletal muscles than clenbuterol

James G. Ryall1, Paul Gregorevic1, David R. Plant1, Martin N. Sillence2, and Gordon S. Lynch1

1 Department of Physiology, The University of Melbourne, Melbourne, Victoria 3010; and 2 School of Agriculture, Charles Sturt University, Wagga Wagga, New South Wales 2678, Australia

Potential treatments for skeletal muscle wasting and weakness ideally possess both anabolic and ergogenic properties. Although the beta 2-adrenoceptor agonist clenbuterol has well-characterized effects on skeletal muscle, less is known about the therapeutic potential of the related beta 2-adrenoceptor agonist fenoterol. We administered an equimolar dose of either clenbuterol or fenoterol to rats for 4 wk to compare their effects on skeletal muscle and tested the hypothesis that fenoterol would produce more powerful anabolic and ergogenic effects. Clenbuterol treatment increased fiber cross-sectional area (CSA) by 6% and maximal isometric force (Po) by 20% in extensor digitorum longus (EDL) muscles, whereas fiber CSA in soleus muscles decreased by 3% and Po was unchanged, compared with untreated controls. In the EDL muscles, fenoterol treatment increased fiber CSA by 20% and increased Po by 12% above values achieved after clenbuterol treatment. Soleus muscles of fenoterol-treated rats exhibited a 13% increase in fiber CSA and a 17% increase in Po above that of clenbuterol-treated rats. These data indicate that fenoterol has greater effects on the functional properties of rat skeletal muscles than clenbuterol.

beta -adrenoceptor; fiber type; skeletal muscle; hypertrophy; muscle wasting; plasticity; muscle contraction


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