| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226
The control of renal medullary perfusion and the impact of alterations in medullary blood flow on renal function have been topics of research interest for almost four decades. Many studies have examined the vascular architecture of the renal medulla, the factors that regulate renal medullary blood flow, and the influence of medullary perfusion on sodium and water excretion and arterial pressure. Despite these studies, there are still a number of important unanswered questions in regard to the control of medullary perfusion and the influence of medullary blood flow on renal excretory function and blood pressure. This review will first address the vascular architecture of the renal medulla and the potential mechanisms whereby medullary perfusion may be regulated. The known extrarenal and local systems that influence the medullary vasculature will then be summarized. Finally, this review will present an overview of the evidence supporting the concept that selective changes in medullary perfusion can have a potent influence on sodium and water excretion with a long-term influence on arterial blood pressure regulation.
kidney; renal hemodynamics; renal medullary blood flow; hypertension
This article has been cited by other articles:
|
|
 |
|
  D. C. Lieb, B. A. Kemp, N. L. Howell, J. J. Gildea, and R. M. Carey Reinforcing Feedback Loop of Renal Cyclic Guanosine 3' 5' -Monophosphate and Interstitial Hydrostatic Pressure in Pressure-Natriuresis Hypertension, December 1, 2009; 54(6): 1278 - 1283. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. R. Pechman, C. De Miguel, H. Lund, E. C. Leonard, D. P. Basile, and D. L. Mattson Recovery from renal ischemia-reperfusion injury is associated with altered renal hemodynamics, blunted pressure natriuresis, and sodium-sensitive hypertension Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2009; 297(5): R1358 - R1363. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Sullivan, B. Wang, E. I. Boesen, G. D'Angelo, J. S. Pollock, and D. M. Pollock Novel use of ultrasound to examine regional blood flow in the mouse kidney Am J Physiol Renal Physiol, July 1, 2009; 297(1): F228 - F235. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Michaels, G. A. Eppel, S. L. Burke, G. A. Head, J. Armitage, J. F. Carroll, S. C. Malpas, and R. G. Evans Altered responsiveness of the kidney to activation of the renal nerves in fat-fed rabbits Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2009; 296(6): R1889 - R1896. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sendeski, A. Patzak, T. L. Pallone, C. Cao, A. E. Persson, and P. B. Persson Iodixanol, Constriction of Medullary Descending Vasa Recta, and Risk for Contrast Medium-induced Nephropathy Radiology, June 1, 2009; 251(3): 697 - 704. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Nakano and D. M. Pollock Contribution of Endothelin A Receptors in Endothelin 1-Dependent Natriuresis in Female Rats Hypertension, February 1, 2009; 53(2): 324 - 330. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Xia, P.-L. Li, and N. Li Telemetric signal-driven servocontrol of renal perfusion pressure in acute and chronic rat experiments Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2008; 295(5): R1494 - R1501. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. G. Evans, B. S. Gardiner, D. W. Smith, and P. M. O'Connor Intrarenal oxygenation: unique challenges and the biophysical basis of homeostasis Am J Physiol Renal Physiol, November 1, 2008; 295(5): F1259 - F1270. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. T. Sims, N. J. Rehrer, M. L. Bell, and J. D. Cotter Endogenous and exogenous female sex hormones and renal electrolyte handling: effects of an acute sodium load on plasma volume at rest J Appl Physiol, July 1, 2008; 105(1): 121 - 127. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Li, L. Chen, F. Yi, M. Xia, and P.-L. Li Salt-Sensitive Hypertension Induced by Decoy of Transcription Factor Hypoxia-Inducible Factor-1{alpha} in the Renal Medulla Circ. Res., May 9, 2008; 102(9): 1101 - 1108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Bourque, M. Komolova, K. Nakatsu, and M. A. Adams Long-Term Circulatory Consequences of Perinatal Iron Deficiency in Male Wistar Rats Hypertension, January 1, 2008; 51(1): 154 - 159. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. G. Evans, S. L. Burke, G. W. Lambert, and G. A. Head Renal responses to acute reflex activation of renal sympathetic nerve activity and renal denervation in secondary hypertension Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1247 - R1256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Burke, G. A. Head, G. W. Lambert, and R. G. Evans Renal Sympathetic Neuroeffector Function in Renovascular and Angiotensin II-Dependent Hypertension in Rabbits Hypertension, April 1, 2007; 49(4): 932 - 938. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Li, F. Yi, E. A. dos Santos, D. K. Donley, and P.-L. Li Role of Renal Medullary Heme Oxygenase in the Regulation of Pressure Natriuresis and Arterial Blood Pressure Hypertension, January 1, 2007; 49(1): 148 - 154. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. B. Persson Fluid volume or arterial pressure, that is the question J. Physiol., September 1, 2005; 567(2): 361 - 361. [Full Text] [PDF]
|
|
|
|
|
|
N. W. Rajapakse, A. K. Sampson, G. A. Eppel, and R. G. Evans Angiotensin II and nitric oxide in neural control of intrarenal blood flow Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2005; 289(3): R745 - R754. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Lee-Kwon, J. B. Wade, Z. Zhang, T. L. Pallone, and E. J. Weinman Expression of TRPC4 channel protein that interacts with NHERF-2 in rat descending vasa recta Am J Physiol Cell Physiol, April 1, 2005; 288(4): C942 - C949. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Zhang and T. L. Pallone Response of descending vasa recta to luminal pressure Am J Physiol Renal Physiol, September 1, 2004; 287(3): F535 - F542. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. W. Rajapakse, R. J. Roman, J. R. Falck, J. J. Oliver, and R. G. Evans Modulation of V1-receptor-mediated renal vasoconstriction by epoxyeicosatrienoic acids Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2004; 287(1): R181 - R187. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. B. Persson The kidney and hypertension Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2003; 284(5): R1176 - R1178. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
