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Am J Physiol Regul Integr Comp Physiol 284: R233-R244, 2003. First published September 27, 2002; doi:10.1152/ajpregu.00061.2002
0363-6119/03 $5.00
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Vol. 284, Issue 1, R233-R244, January 2003

Autoregulation of renal medullary blood flow in rabbits

Gabriela A. Eppel1, Göran Bergström2, Warwick P. Anderson1, and Roger G. Evans1

1 Department of Physiology, Monash University, Melbourne, Australia; and 2 Department of Physiology, Institute of Physiology and Pharmacology, University of Göteborg, Göteborg, Sweden

We examined the extent of renal medullary blood flow (MBF) autoregulation in pentobarbital-anesthetized rabbits. Two methods for altering renal arterial pressure (RAP) were compared: the conventional method of graded suprarenal aortic occlusion and an extracorporeal circuit that allows RAP to be increased above systemic arterial pressure. Changes in MBF were estimated by laser-Doppler flowmetry, which appears to predominantly reflect erythrocyte velocity, rather than flow, in the kidney. We compared responses using a dual-fiber needle probe held in place by a micromanipulator, with responses from a single-fiber probe anchored to the renal capsule, to test whether RAP-induced changes in kidney volume confound medullary laser-Doppler flux (MLDF) measurements. MLDF responses were similar for both probe types and both methods for altering RAP. MLDF changed little as RAP was altered from 50 to >= 170 mmHg (24 ± 22% change). Within the same RAP range, RBF increased by 296 ± 48%. Urine flow and sodium excretion also increased with increasing RAP. Thus pressure diuresis/natriuresis proceeds in the absence of measurable increases in medullary erythrocyte velocity estimated by laser-Doppler flowmetry. These data do not, however, exclude the possibility that MBF is increased with increasing RAP in this model, because vasa recta recruitment may occur.

laser-Doppler flowmetry; pressure diuresis; renal blood flow; renal perfusion pressure; renal medulla


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