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Am J Physiol Regul Integr Comp Physiol 284: R51-R56, 2003. First published October 3, 2002; doi:10.1152/ajpregu.00427.2002
0363-6119/03 $5.00
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Vol. 284, Issue 1, R51-R56, January 2003

Ontogeny and effect of cortisol on vasopressin-1b receptor expression in anterior pituitaries of fetal sheep

Sharla F. Young1, Jennifer L. Smith2, Jorge P. Figueroa2, and James C. Rose1,2

1 Departments of Physiology/Pharmacology and of 2 Obstetrics/Gynecology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157

Corticotroph responsiveness to arginine vasopressin (AVP) increases during late gestation in fetal sheep. The mechanism of this increase in AVP responsiveness is currently unknown but could be related to an increase in vasopressin type 1b (V1b) receptor expression in the pituitary during development. To determine if there are ontogenic changes in V1b receptor expression that may help explain the changes in ACTH responses to AVP, we studied pituitaries from three groups of fetal sheep [100, 120, or 140 days gestational age (dGA)]. V1b receptor mRNA and protein significantly decreased by 140 dGA. Peak V1b mRNA levels were detected at 100 dGA, while peak V1b protein levels were detected at 120 dGA. The reduction in V1b receptor expression in late gestation may be due to the naturally occurring peripartum increase in fetal plasma cortisol because cortisol infusion at 122-130 dGA decreased V1b receptor mRNA. Thus there is a marked decrease in the expression of the V1b receptor in the pituitary during fetal development, leaving the role of the V1b receptor in increasing AVP responsiveness uncertain.

hypothalamic-pituitary-adrenal axis; arginine vasopressin; corticotroph


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S. F. Young, S. B. Tatter, N. K. Valego, J. P. Figueroa, J. Thompson, and J. C. Rose
The role of hypothalamic input on corticotroph maturation in fetal sheep
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2003; 284(6): R1621 - R1630.
[Abstract] [Full Text] [PDF]


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