AJP - Regu Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 284: R363-R371, 2003. First published September 27, 2002; doi:10.1152/ajpregu.00247.2002
0363-6119/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
284/2/R363    most recent
00247.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (16)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gillingham, M. B.
Right arrow Articles by Ney, D. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gillingham, M. B.
Right arrow Articles by Ney, D. M.
Vol. 284, Issue 2, R363-R371, February 2003

IGF-I treatment facilitates transition from parenteral to enteral nutrition in rats with short bowel syndrome

Melanie B. Gillingham, Elizabeth M. Dahly, Sangita G. Murali, and Denise M. Ney

Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53706

The goal of growth factor treatment in patients with short bowel syndrome (SBS) is to facilitate transition from parenteral to enteral feedings. Ideal use of growth factors would be acute treatment that produces sustained effects. We investigated the ability of acute insulin-like growth factor I (IGF-I) treatment to facilitate weaning from total parenteral nutrition (TPN) to enteral feeding in a rat model of SBS. After a 60% jejunoileal resection + cecectomy, rats treated with IGF-I or vehicle were maintained exclusively with TPN for 4 days and transitioned to oral feeding. TPN and IGF-I were stopped 7 days after resection, and rats were maintained with oral feeding for 10 more days. In IGF-I-treated rats, serum concentration of IGF-I and final body weight were significantly greater because of a proportionate increase in carcass lean body mass than in vehicle-treated rats. Acute IGF-I treatment induced sustained jejunal hyperplasia on the basis of significantly greater concentrations of jejunal mucosal protein and DNA without a change in histology or sucrase activity. These results demonstrate that acute IGF-I facilitates weaning from parenteral to enteral nutrition in association with maintenance of a greater body weight and serum IGF-I concentration in rats with SBS.

intestinal adaptation; distal small bowel resection; body composition


This article has been cited by other articles:


Home page
 JPEN J Parenter Enteral NutrHome page
P. M. Pereira-Fantini, S. L. Thomas, R. G. Taylor, E. Nagy, M. Sourial, P. J. Fuller, and J. E. Bines
Colostrum Supplementation Restores Insulin-like Growth Factor -1 Levels and Alters Muscle Morphology Following Massive Small Bowel Resection
JPEN J Parenter Enteral Nutr, May 1, 2008; 32(3): 266 - 275.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. G. Murali, X. Liu, D. W. Nelson, A. K. Hull, M. Grahn, M. K. Clayton, J. E. Pintar, and D. M. Ney
Intestinotrophic effects of exogenous IGF-I are not diminished in IGF binding protein-5 knockout mice
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2007; 292(6): R2144 - R2150.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. Tian, N. Washizawa, L. H. Gu, M. S. Levin, L. Wang, D. C. Rubin, S. Mwangi, S. Srinivasan, Y. Gao, D. P. Jones, et al.
Stimulation of colonic mucosal growth associated with oxidized redox status in rats
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2007; 292(3): R1081 - R1091.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
J. Tian, N. Washizawa, L. H. Gu, M. S. Levin, L. Wang, D. C. Rubin, S. Mwangi, S. Srinivasan, D. P. Jones, and T. R. Ziegler
Local Glutathione Redox Status Does Not Regulate Ileal Mucosal Growth after Massive Small Bowel Resection in Rats
J. Nutr., February 1, 2007; 137(2): 320 - 325.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
C. Z. Michaylira, J. G. Simmons, N. M. Ramocki, B. P. Scull, K. K. McNaughton, C. R. Fuller, and P. K. Lund
Suppressor of cytokine signaling-2 limits intestinal growth and enterotrophic actions of IGF-I in vivo
Am J Physiol Gastrointest Liver Physiol, September 1, 2006; 291(3): G472 - G481.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. Fruchtman, J. G. Simmons, C. Z. Michaylira, M. E. Miller, C. J. Greenhalgh, D. M. Ney, and P. K. Lund
Suppressor of cytokine signaling-2 modulates the fibrogenic actions of GH and IGF-I in intestinal mesenchymal cells
Am J Physiol Gastrointest Liver Physiol, August 1, 2005; 289(2): G342 - G350.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
E. M. Dahly, Z. Guo, and D. M. Ney
IGF-I augments resection-induced mucosal hyperplasia by altering enterocyte kinetics
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2003; 285(4): R800 - R808.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
G. S. Howarth
Insulin-Like Growth Factor-I and the Gastrointestinal System: Therapeutic Indications and Safety Implications
J. Nutr., July 1, 2003; 133(7): 2109 - 2112.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online