| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Psychology and Center for Neuroscience, University of Colorado, Boulder, Colorado 80309-0345
It has recently been reported that exposure to inescapable tailshock (IS) enhances the release of proinflammatory cytokines following bacterial challenge. However, it is not known whether the level of potentiation of proinflammatory cytokines is sufficient to exaggerate any of the physiological processes that are regulated by these cytokines. Thus, LPS was administered and fever, activity, hypothalamic-pituitary-adrenal (HPA) responses, and proinflammatory cytokine release were assessed during both the light and dark phases of the light cycle following IS. Exposure to IS resulted in elevated basal core body temperature during the light phase but not the dark phase and decreased activity during the dark phase but not the light phase. IS animals had significantly greater fever, corticosterone, and ACTH responses following LPS during both the light and dark phases, whereas enhanced proinflammatory cytokine responses were only observed during the light phase. These data suggest that enhanced proinflammatory cytokine responses are not necessary to observe enhanced HPA or fever responses.
activity; inescapable tailshock; circadian rhythm; hypothalamic-pituitary-adrenal axis
This article has been cited by other articles:
|
|
 |
|
  D. A. Gray, S. K. Maloney, and P. R. Kamerman Restraint increases afebrile body temperature but attenuates fever in Pekin ducks (Anas platyrhynchos) Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2008; 294(5): R1666 - R1671. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Tavares, F. J. Minano, R. Maldonado, and M. J. Dascombe Endotoxin fever in granulocytopenic rats: evidence that brain cyclooxygenase-2 is more important than circulating prostaglandin E2 J. Leukoc. Biol., December 1, 2006; 80(6): 1375 - 1387. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Y. Rudaya, A. A. Steiner, J. R. Robbins, A. S. Dragic, and A. A. Romanovsky Thermoregulatory responses to lipopolysaccharide in the mouse: dependence on the dose and ambient temperature Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2005; 289(5): R1244 - R1252. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Rummel, S. W. Barth, T. Voss, S. Korte, R. Gerstberger, T. Hubschle, and J. Roth Localized vs. systemic inflammation in guinea pigs: a role for prostaglandins at distinct points of the fever induction pathways? Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2005; 289(2): R340 - R347. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Romanovsky Anorexia: the toll for lipopolysaccharide recognition Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2004; 287(2): R274 - R275. [Full Text] [PDF]
|
|
|
|
 |
|
 C. Rummel, T. Hubschle, R. Gerstberger, and J. Roth Nuclear translocation of the transcription factor STAT3 in the guinea pig brain during systemic or localized inflammation J. Physiol., June 1, 2004; 557(2): 671 - 687. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Campisi,, M. K. Hansen,, K. A. O'Connor,, J. C. Biedenkapp,, L. R. Watkins,, S. F. Maier,, and M. Fleshner Circulating cytokines and endotoxin are not necessary for the activation of the sickness or corticosterone response produced by peripheral E. coli challenge J Appl Physiol, November 1, 2003; 95(5): 1873 - 1882. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Romanovsky and S. R. Petersen The spleen: another mystery about its function Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2003; 284(6): R1378 - R1379. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
