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Am J Physiol Regul Integr Comp Physiol 284: R607-R610, 2003; doi:10.1152/ajpregu.00578.2002
0363-6119/03 $5.00
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Vol. 284, Issue 2, R607-R610, February 2003

REPORT
Expression of smooth muscle MyHC B in blood vessels of hypertrophied heart in experimentally hypertensive rats

Katharina Wetzel1, Ovidiu Baltatu1, Benno Nafz2, Pontus B. Persson2, Hannelore Haase1, and Ingo Morano1,2

1 Max Delbrück Center for Molecular Medicine, 13122 Berlin-Buch; and 2 Johannes-Müller-Institute of Physiology, Humboldt-University, Medical Faculty (Charité), Berlin, Germany

We demonstrated recently a significantly lower fraction of cardiac precapillary arterioles that expressed smooth muscle myosin heavy chain (MyHC) B (SMB) in spontaneously hypertensive rats. To clarify whether this reduction of SMB expression is of genetic origin, we investigated SMB expression in cardiac precapillary arterioles of normotensive and experimentally hypertensive rats (one clip, one kidney or ANG II minipump). We observed similar SMB expression patterns in precapillary arterioles of experimentally hypertensive rats compared with normotensive controls. These observations suggest that the downregulation of SMB in spontaneously hypertensive rats is of genetic origin rather than an adaptive response to chronically enhanced blood pressure and cardiac hypertrophy.

hypertrophy; hypertension; myosin heavy chain




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