AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 284: R792-R801, 2003; doi:10.1152/ajpregu.00060.2002
0363-6119/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (18)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Flück, M.
Right arrow Articles by Desplanches, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Flück, M.
Right arrow Articles by Desplanches, D.
Vol. 284, Issue 3, R792-R801, March 2003

Reloading of atrophied rat soleus muscle induces tenascin-C expression around damaged muscle fibers

Martin Flück1,2, Matthias Chiquet1, Silvia Schmutz2, Marie-Hélène Mayet-Sornay3, and Dominique Desplanches3

1 M. E. Müller-Institute for Biomechanics, 2 Department of Anatomy, University of Bern, 3000 Bern 9, Switzerland; and 3 Unité Mixte de Recherche 5123, Centre National de la Recherche Scientifique, Faculté de Médecine, Université Lyon 1, 69008 Lyon, France

The hypothesis was tested that mechanical loading, induced by hindlimb suspension and subsequent reloading, affects expression of the basement membrane components tenascin-C and fibronectin in the belly portion of rat soleus muscle. One day of reloading, but not the previous 14 days of hindlimb suspension, led to ectopic accumulation of tenascin-C and an increase of fibronectin in the endomysium of a proportion (8 and 15%) of muscle fibers. Large increases of tenascin-C (40-fold) and fibronectin (7-fold) mRNA within 1 day of reloading indicates the involvement of pretranslational mechanisms in tenascin-C and fibronectin accumulation. The endomysial accumulation of tenascin-C was maintained up to 14 days of reloading and was strongly associated with centrally nucleated fibers. The observations demonstrate that an unaccustomed increase of rat soleus muscle loading causes modification of the basement membrane of damaged muscle fibers through ectopic endomysial expression of tenascin-C.

mechanical stress; fibroblast; extracellular matrix


This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
R. Trepp, M. Fluck, C. Stettler, C. Boesch, M. Ith, R. Kreis, H. Hoppeler, H. Howald, J.-P. Schmid, P. Diem, et al.
Effect of GH on human skeletal muscle lipid metabolism in GH deficiency
Am J Physiol Endocrinol Metab, June 1, 2008; 294(6): E1127 - E1134.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. M. McClung, J. M. Davis, M. A. Wilson, E. C. Goldsmith, and J. A. Carson
Estrogen status and skeletal muscle recovery from disuse atrophy
J Appl Physiol, June 1, 2006; 100(6): 2012 - 2023.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. Scholz
Unraveling the basic principles
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2006; 290(6): R1485 - R1487.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. Zoll, E. Ponsot, S. Dufour, S. Doutreleau, R. Ventura-Clapier, M. Vogt, H. Hoppeler, R. Richard, and M. Fluck
Exercise training in normobaric hypoxia in endurance runners. III. Muscular adjustments of selected gene transcripts
J Appl Physiol, April 1, 2006; 100(4): 1258 - 1266.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Fluck, C. Dapp, S. Schmutz, E. Wit, and H. Hoppeler
Transcriptional profiling of tissue plasticity: role of shifts in gene expression and technical limitations
J Appl Physiol, August 1, 2005; 99(2): 397 - 413.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M.-N. Giraud, M. Fluck, C. Zuppinger, and T. M. Suter
Expressional reprogramming of survival pathways in rat cardiocytes by neuregulin-1{beta}
J Appl Physiol, July 1, 2005; 99(1): 313 - 322.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Fluck, S. Schmutz, M. Wittwer, H. Hoppeler, and D. Desplanches
Transcriptional reprogramming during reloading of atrophied rat soleus muscle
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2005; 289(1): R4 - R14.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Y.-W. Chen, M. J. Hubal, E. P. Hoffman, P. D. Thompson, and P. M. Clarkson
Molecular responses of human muscle to eccentric exercise
J Appl Physiol, December 1, 2003; 95(6): 2485 - 2494.
[Abstract] [Full Text]

Home page
 Physiol. GenomicsHome page
B. Schmitt, M. Fluck, J. Decombaz, R. Kreis, C. Boesch, M. Wittwer, F. Graber, M. Vogt, H. Howald, and H. Hoppeler
Transcriptional adaptations of lipid metabolism in tibialis anterior muscle of endurance-trained athletes
Physiol Genomics, October 17, 2003; 15(2): 148 - 157.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
M. Chiquet and M. Fluck
Ectopic expression of tenascin-C
J. Cell Sci., October 1, 2003; 116(19): 3851 - 3851.
[Full Text] [PDF]

Home page
 J. Cell Sci.Home page
T. A. H. Jarvinen, T. L. N. Jarvinen, P. Kannus, and H. Kalimo
Reply
J. Cell Sci., October 1, 2003; 116(19): 3851 - 3853.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online