| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157
The importance of prostaglandins in the
regulation of the renin-angiotensin system during development is not
known. These experiments were conducted to examine the effects of
prostaglandin synthesis inhibitors on basal and isoproterenol-induced
plasma renin concentration and renin gene expression in the
late-gestation fetal lamb. Eighteen lamb fetuses ranging in gestational
age from 129 to 138 days underwent surgical insertion of femoral
arterial and venous catheters under general endotracheal anesthesia.
After a period of recovery, animals underwent an infusion of
isoproterenol after administration of a saline bolus (control
experiments); 24-48 h later a second study was performed after
administration of NS-398, a cyclooxygenase (COX)-2 inhibitor, or saline
for a second control study. Administration of COX-2 inhibitor
significantly reduced baseline plasma renin levels and attenuated
responses in fetal renin secretion to isoproterenol infusions. Renal
cortical cells from animals receiving COX-2 inhibitor had significantly lower levels of renin mRNA compared with animals receiving only saline.
Renal cortical cells in culture from animals receiving only saline
exhibited increased levels of renin mRNA when treated with
isoproterenol, forskolin, or IBMX. Only forskolin increased renin mRNA
levels in renal cortical cells in culture from animals receiving COX-2
inhibitor. We conclude that prostaglandins play a stimulatory role in
the regulation of the renin-angiotensin system and are necessary for
-adrenergic stimulation of renin secretion and gene expression in
the late-gestation fetal lamb.
NS-398; isoproterenol; -adrenergic stimulation; kidney; development
This article has been cited by other articles:
|
|
 |
|
  L. C. Carey, N. K. Valego, Kai Chen, and J. C. Rose Thyroid Hormone Regulates Renocortical COX-2 and PGE2 Expression in the Late Gestation Fetal Sheep Reproductive Sciences, July 1, 2008; 15(6): 598 - 603. [Abstract] [PDF]
|
|
|
|
 |
|
 R. C. Harris and M. D. Breyer Update on Cyclooxygenase-2 Inhibitors Clin. J. Am. Soc. Nephrol., March 1, 2006; 1(2): 236 - 245. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Chen, L. C. Carey, N. K. Valego, J. Liu, and J. C. Rose Thyroid hormone modulates renin and ANG II receptor expression in fetal sheep Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2005; 289(4): R1006 - R1014. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-Z. Zhang, S.-w. Wang, H. Cheng, Y. Zhang, J. A. McKanna, and R. C. Harris Regulation of renal cortical cyclooxygenase-2 in young rats Am J Physiol Renal Physiol, November 1, 2003; 285(5): F881 - F888. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. B. Persson The kidney and hypertension Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2003; 284(5): R1176 - R1178. [Full Text] [PDF]
|
|
|
|
|
|
H. M. Stauss Interaction of prostaglandins with the renin-angiotensin system Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2003; 284(4): R1010 - R1011. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
