AJP - Regu Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 284: R1037-R1042, 2003. First published January 9, 2003; doi:10.1152/ajpregu.00480.2002
0363-6119/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
284/4/R1037    most recent
00480.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (9)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kuo, J. J.
Right arrow Articles by Hall, J. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kuo, J. J.
Right arrow Articles by Hall, J. E.
Vol. 284, Issue 4, R1037-R1042, April 2003

Chronic cardiovascular and renal actions of leptin during hyperinsulinemia

Jay J. Kuo, O. Barrett Jones, and John E. Hall

Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216

Hyperinsulinemia and hyperleptinemia occur concurrently in obese subjects, and both have been suggested to mediate increased blood pressure associated with excess weight gain. The goal of this study was to determine whether chronic hyperleptinemia exacerbates the effects of insulin on arterial pressure and renal function. Group I and II rats were infused with insulin (1.5 mU · kg-1 · min-1) for 21 days while maintaining euglycemia. After 7 days of insulin infusion, group II rats received leptin (1.0 µg · kg-1 · min-1) for 7 days, concomitant with insulin. Insulin plus glucose infusion reduced food intake to 55 ± 7% of control, while leptin + insulin lowered food intake further to 22 ± 4% of the initial control. Insulin initially raised mean arterial pressure (MAP) by 12 ± 1 mmHg; then MAP declined to 5-8 mmHg above control during continued hyperinsulinemia. Leptin + insulin infusion increased MAP by 7 ± 2 mmHg above the level observed in rats infused with insulin alone. Insulin raised heart rate (HR) by 17 ± 5 beats/min, whereas leptin + insulin increased HR by 34 ± 5 beats/min. Thus leptin appears to increase the effects of insulin to suppress appetite and to raise arterial pressure and HR.

blood pressure; heart rate; food intake; obesity; hypertension; kidney


This article has been cited by other articles:


Home page
 HypertensionHome page
M. Pravenec and T. W. Kurtz
Molecular Genetics of Experimental Hypertension and the Metabolic Syndrome: From Gene Pathways to New Therapies
Hypertension, May 1, 2007; 49(5): 941 - 952.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
F. Dong, X. Zhang, and J. Ren
Leptin Regulates Cardiomyocyte Contractile Function Through Endothelin-1 Receptor-NADPH Oxidase Pathway
Hypertension, February 1, 2006; 47(2): 222 - 229.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
A. P. Rocchini, J. Q. Yang, and A. Gokee
Hypertension and Insulin Resistance Are Not Directly Related in Obese Dogs
Hypertension, May 1, 2004; 43(5): 1011 - 1016.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online