AJP - Regu Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 284: R1384-R1388, 2003; doi:10.1152/ajpregu.00689.2002
0363-6119/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (6)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cannon, C. M.
Right arrow Articles by Palmiter, R. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cannon, C. M.
Right arrow Articles by Palmiter, R. D.
Vol. 284, Issue 6, R1384-R1388, June 2003

SPECIAL TOPICS
Peptides that Regulate Food Intake
Norepinephrine is not required for reduction of feeding induced by cholecystokinin

C. Matson Cannon and R. D. Palmiter

Department of Biochemistry, Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195-7370

CCK octapeptide (CCK-8) is released by the gut in response to a meal and acts via CCKA receptors on vagal afferents to induce satiety. However, the central neural pathways by which peripheral CCK-8 affects feeding are poorly understood. In the present study, we tested the hypothesis that norepinephrine (NE) is necessary for satiety induced by peripheral CCK-8 by using mice lacking dopamine beta -hydroxylase (Dbh-/-), the enzyme responsible for synthesizing NE and epinephrine from dopamine. We found that Dbh-/- mice are as responsive to the satiating effects of CCK-8 as their normal littermates.

knockout mice; cholecystokinin-8; norepinephrine; dopamine beta -hydroxylase


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
W. A. Cupples
Physiological regulation of food intake
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2005; 288(6): R1438 - R1443.
[Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. Rinaman
Hindbrain Noradrenergic Lesions Attenuate Anorexia and Alter Central cFos Expression in Rats after Gastric Viscerosensory Stimulation
J. Neurosci., November 5, 2003; 23(31): 10084 - 10092.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
W. A. Cupples
Peptides that regulate food intake
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2003; 284(6): R1370 - R1374.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2003 by the American Physiological Society.