HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Supplemental Figures Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (9) Citing Articles via Google Scholar Google Scholar Articles by Takenaka, T. Articles by Suzuki, H. Search for Related Content PubMed PubMed Citation Articles by Takenaka, T. Articles by Suzuki, H.

LOCAL CONTROL OF CIRCULATION

Governance of arteriolar oscillation by ryanodine receptors

¹Department of Medicine, Saitama Medical College, Iruma, Saitama 350–0495; and ²Department of Medicine, School of Medicine, Keio University, Shinjuku, Tokyo 160-8582, Japan

Submitted 25 November 2002 ; accepted in final form 13 February 2003

To investigate the role of ryanodine receptors in glomerular arterioles, experiments were performed using an isolated perfused hydronephrotic kidney model. In the first series of studies, BAYK-8644 (300 nM), a calcium agonist, constricted afferent (19.6 ± 0.6 to 17.6 ± 0.5 µm, n = 6, P < 0.01) but not efferent arterioles. Furthermore, BAYK-8644 elicited afferent arteriolar oscillatory movements. Subsequent administration of nifedipine (1 µM) inhibited both afferent arteriolar oscillation and constriction by BAYK-8644 (to 19.4 ± 0.5 µm). In the second group, although BAYK-8644 constricted afferent arterioles treated with 1 µM of thapsigargin (19.7 ± 0.6 to 16.8 ± 0.6 µm, n = 5, P < 0.05), it failed to induce rhythmic contraction. Removal of extracellular calcium with EGTA (2 mM) reversed BAYK-8644-induced afferent arteriolar constriction (to 20.0 ± 0.5 µm). In the third series of investigations, ryanodine (10 µM) but not 2-aminoethoxyphenyl borate (100 µM) abolished afferent arteriolar vasomotion by BAYK-8644. In the fourth series of experiments, in the presence of caffeine (1 mM), the stronger activation of voltage-dependent calcium channels by higher potassium media resulted in greater afferent arteriolar constriction and faster oscillation. Our results indicate that L-type calcium channels are rich in preglomerular but not postglomerular microvessels. Furthermore, the present findings suggest that either prolonged calcium influx through voltage-dependent calcium channels (BAYK-8644) or sensitized ryanodine receptors (caffeine) is required to trigger periodic calcium release through ryanodine receptors in afferent arterioles.

glomerular circulation; voltage-dependent calcium channel; caffeine; BAYK-8644; tubuloglomerular feedback

This article has been cited by other articles:

				J. Satriano, R. Cunard, O. W. Peterson, T. Dousa, F. B. Gabbai, and R. C. Blantz Effects on kidney filtration rate by agmatine requires activation of ryanodine channels for nitric oxide generation Am J Physiol Renal Physiol, April 1, 2008; 294(4): F795 - F800. [Abstract] [Full Text] [PDF]

				T. Takenaka, T. Inoue, Y. Kanno, H. Okada, C. E. Hill, and H. Suzuki Connexins 37 and 40 transduce purinergic signals mediating renal autoregulation Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2008; 294(1): R1 - R11. [Abstract] [Full Text] [PDF]

				X. Wang, R. D. Loutzenhiser, and W. A. Cupples Frequency modulation of renal myogenic autoregulation by perfusion pressure Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1199 - R1204. [Abstract] [Full Text] [PDF]

				S. K. Fellner and W. J. Arendshorst Voltage-gated Ca2+ entry and ryanodine receptor Ca2+-induced Ca2+ release in preglomerular arterioles Am J Physiol Renal Physiol, May 1, 2007; 292(5): F1568 - F1572. [Abstract] [Full Text] [PDF]

				T. Takenaka, H. Okada, Y. Kanno, T. Inoue, M. Ryuzaki, H. Nakamoto, H. Kawachi, F. Shimizu, and H. Suzuki Exogenous 5'-nucleotidase improves glomerular autoregulation in Thy-1 nephritic rats Am J Physiol Renal Physiol, April 1, 2006; 290(4): F844 - F853. [Abstract] [Full Text] [PDF]

				O. Lisy and J. C. Burnett Jr New Cardioprotective Agent K201 Is Natriuretic and Glomerular Filtration Rate Enhancing Circulation, January 17, 2006; 113(2): 246 - 251. [Abstract] [Full Text] [PDF]

				R. E Haddock and C. E Hill Rhythmicity in arterial smooth muscle J. Physiol., August 1, 2005; 566(3): 645 - 656. [Abstract] [Full Text] [PDF]

				S. K. Fellner and W. J. Arendshorst Angiotensin II Ca2+ signaling in rat afferent arterioles: stimulation of cyclic ADP ribose and IP3 pathways Am J Physiol Renal Physiol, April 1, 2005; 288(4): F785 - F791. [Abstract] [Full Text] [PDF]