AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 285: R262-R270, 2003; doi:10.1152/ajpregu.00692.2001
0363-6119/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (12)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sato, T.
Right arrow Articles by Sunagawa, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sato, T.
Right arrow Articles by Sunagawa, K.

NEUROHUMORAL CONTROL OF CIRCULATION AND HYPERTENSION
Innovative Methodology

Dynamics of sympathetic baroreflex control of arterial pressure in rats

Takayuki Sato,1,2 Toru Kawada,1 Masashi Inagaki,1 Toshiaki Shishido,1 Masaru Sugimachi,1 and Kenji Sunagawa1

1Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, Suita, Osaka 565-8565, and 2Department of Cardiovascular Control, Kochi Medical School, Nankoku, Kochi 783-8505, Japan

Submitted 19 November 2001 ; accepted in final form 10 March 2003

By a white noise approach, we characterized the dynamics of the sympathetic baroreflex system in 11 halothane-anesthetized rats. We measured sympathetic nerve activity (SNA) and systemic arterial pressure (SAP), while carotid sinus baroreceptor pressure (BRP) was altered randomly. We estimated the transfer functions from BRP to SNA (mechanoneural arc), from SNA to SAP (neuromechanical arc), and from BRP to SAP (total arc). The gain of the mechanoneural arc gradually increased about threefold as the frequency of BRP change increased from 0.01 to 0.8 Hz. In contrast, the gain of the neuromechanical arc rapidly decreased to 0.4% of the steady-state gain as the frequency increased from 0.01 to 1 Hz. Although the total arc also had low-pass characteristics, the rate of attenuation in its gain was significantly slower than that of the neuromechanical arc, reflecting the compensatory effect of the mechanoneural arc for the sluggish response of the neuromechanical arc. We conclude that the quantitative estimation of the baroreflex dynamics is vital for an integrative understanding of baroreflex function in rats.

baroreflex sensitivity; dynamic system; feedback system; mechanoneural arc; neuromechanical arc


Address for reprint requests and other correspondence: T. Sato, Dept. of Cardiovascular Control, Kochi Medical School, Nankoku, Kochi 783-8505, Japan (E-mail:tacsato-kochimed{at}umin.ac.jp).




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
V. Orea, R. Kanbar, B. Chapuis, C. Barres, and C. Julien
Transfer function analysis between arterial pressure and renal sympathetic nerve activity at cardiac pacing frequencies in the rat
J Appl Physiol, March 1, 2007; 102(3): 1034 - 1040.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
K. van Heusden, J. Gisolf, W. J. Stok, S. Dijkstra, and J. M. Karemaker
Mathematical modeling of gravitational effects on the circulation: importance of the time course of venous pooling and blood volume changes in the lungs
Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2152 - H2165.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. Emonnot, C. Bakhos, B. Chapuis, V. Orea, C. Barres, and C. Julien
Role of purinergic cotransmission in the sympathetic control of arterial pressure variability in conscious rats
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2006; 291(3): R736 - R741.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
C. Julien
The enigma of Mayer waves: Facts and models
Cardiovasc Res, April 1, 2006; 70(1): 12 - 21.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. E. Hammer and J. P. Saul
Resonance in a mathematical model of baroreflex control: arterial blood pressure waves accompanying postural stress
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2005; 288(6): R1637 - R1648.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Y. Yanagiya, T. Sato, T. Kawada, M. Inagaki, T. Tatewaki, C. Zheng, A. Kamiya, H. Takaki, M. Sugimachi, and K. Sunagawa
Bionic epidural stimulation restores arterial pressure regulation during orthostasis
J Appl Physiol, September 1, 2004; 97(3): 984 - 990.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
B. Chapuis, E. Vidal-Petiot, V. Orea, C. Barres, and C. Julien
Linear modelling analysis of baroreflex control of arterial pressure variability in rats
J. Physiol., September 1, 2004; 559(2): 639 - 649.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
T. Kawada, K. Uemura, K. Kashihara, A. Kamiya, M. Sugimachi, and K. Sunagawa
A derivative-sigmoidal model reproduces operating point-dependent baroreflex neural arc transfer characteristics
Am J Physiol Heart Circ Physiol, June 1, 2004; 286(6): H2272 - H2279.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. M. Gotoh, N. Fujiki, T. Matsuda, S. Gao, and H. Morita
Roles of baroreflex and vestibulosympathetic reflex in controlling arterial blood pressure during gravitational stress in conscious rats
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2004; 286(1): R25 - R30.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2003 by the American Physiological Society.