| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
COMPLEX FUNCTIONS OF THE CENTRAL NERVOUS SYSTEM, SLEEP AND LOCOMOTION
1Department of Psychology, Columbia University, 2Department of Psychology, Barnard College, New York 10027; and 3Department of Anatomy and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York 10032
Submitted 16 January 2003 ; accepted in final form 19 March 2003
Daily scheduled feeding is a potent time cue that elicits anticipatory activity in rodents. This food-anticipatory activity (FAA) is controlled by a food-entrainable oscillator (FEO) that is distinct from light-entrained oscillators of the suprachiasmatic nucleus (SCN). Circadian rhythms within the SCN depend on transcription-translation feedback loops in which CLOCK protein is a key positive regulator. The Clock gene is expressed in rhythmic tissues throughout the brain and periphery, implicating its widespread involvement in the functioning of circadian oscillators. To examine whether CLOCK protein is also necessary for the FEO, the effect of daily food restriction was studied in homozygous Clock mutant (Clk/Clk) mice. The results show that Clk/Clk mutant mice exhibit FAA, even when their circadian wheel-running behavior is arrhythmic. As in wild-type controls, FAA in Clk/Clk mutants persists after temporal feeding cues are removed for several cycles, indicating that the FEO is a circadian timer. This is the first demonstration that the Clock gene is not necessary for the expression of a circadian, food-entrained behavior and suggests that the FEO is mediated by a molecular mechanism distinct from that of the SCN.
food-anticipatory activity; feeding; entrainment; clock genes; suprachiasmatic nucleus
This article has been cited by other articles:
|
|
 |
|
  W. J. Sheward, E. S. Maywood, K. L. French, J. M. Horn, M. H. Hastings, J. R. Seckl, M. C. Holmes, and A. J. Harmar Entrainment to Feeding but Not to Light: Circadian Phenotype of VPAC2 Receptor-Null Mice J. Neurosci., April 18, 2007; 27(16): 4351 - 4358. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. B. Saper and P. M. Fuller Inducible Clocks: Living in an Unpredictable World Cold Spring Harb Symp Quant Biol, January 1, 2007; 72(0): 543 - 550. [Abstract] [PDF]
|
|
|
|
 |
|
 Q.-Y. Zhou The Prokineticins: A NOVEL PAIR OF REGULATORY PEPTIDES Mol. Interv., December 1, 2006; 6(6): 330 - 338. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-D. Li, W.-P. Hu, L. Boehmer, M. Y. Cheng, A. G. Lee, A. Jilek, J. M. Siegel, and Q.-Y. Zhou Attenuated Circadian Rhythms in Mice Lacking the Prokineticin 2 Gene. J. Neurosci., November 8, 2006; 26(45): 11615 - 11623. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. J. Landry, M. M. Simon, I. C. Webb, and R. E. Mistlberger Persistence of a behavioral food-anticipatory circadian rhythm following dorsomedial hypothalamic ablation in rats Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2006; 290(6): R1527 - R1534. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Davidson Search for the feeding-entrainable circadian oscillator: a complex proposition Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2006; 290(6): R1524 - R1526. [Full Text] [PDF]
|
|
|
|
 |
|
 P. Franken, C. A. Dudley, S. J. Estill, M. Barakat, R. Thomason, B. F. O'Hara, and S. L. McKnight NPAS2 as a transcriptional regulator of non-rapid eye movement sleep: Genotype and sex interactions PNAS, May 2, 2006; 103(18): 7118 - 7123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. A. Cupples Physiological regulation of food intake Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2005; 288(6): R1438 - R1443. [Full Text] [PDF]
|
|
|
|
|
|
F. K. Stephan Broken circadian clocks: a clock gene mutation and entrainment by feeding Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2003; 285(1): R32 - R33. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
