| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
LOCAL CONTROL OF CIRCULATION
Department of Physiology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112
Submitted 8 October 2002 ; accepted in final form 2 April 2003
Vascular tissues express heme oxygenase, which metabolizes heme to form
carbon monoxide (CO). CO promotes relaxation of vascular smooth muscle but
also inhibits nitric oxide (NO) formation. This study examines the hypothesis
that CO promotes endothelium- and NO synthase-dependent vasoconstriction of
isolated arterioles. Studies were conducted on pressurized first-order
gracilis muscle arterioles isolated from anesthetized male Sprague-Dawley
rats. Exogenous CO, as well as a heme precursor, 
-aminolevulinic acid
(-ALA), constricted arterioles with intact endothelium pretreated with
phenylephrine; these effects were abolished by removal of the endothelium. CO-
and -ALA-induced vasoconstrictions were converted to dilations by
pretreatment with an inhibitor of NO synthase,
N
-nitro-L-arginine methyl ester, or with
N-nitro-L-arginine methyl ester and an
NO donor, sodium nitroprusside. Furthermore, CO-induced vasoconstriction was
prevented by pretreatment with the NO synthase substrate
L-arginine. This study shows that exogenous, as well as
endogenously formed, CO can promote endothelium-dependent vasoconstriction in
isolated gracilis muscle arterioles. Because CO-induced vasoconstriction is
abolished by NO synthase blockade and by L-arginine, CO most likely
promotes endothelium-dependent vasoconstriction by inhibiting endothelial NO
formation.
heme oxygenase; nitric oxide; vascular tone; -aminolevulinic acid
This article has been cited by other articles:
|
|
 |
|
  K. A. Nath, L. V. d'Uscio, J. P. Juncos, A. J. Croatt, M. C. Manriquez, S. T. Pittock, and Z. S. Katusic An analysis of the DOCA-salt model of hypertension in HO-1-/- mice and the Gunn rat Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H333 - H342. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. W. Ryter, D. Morse, and A. M. K. Choi Carbon Monoxide and Bilirubin: Potential Therapies for Pulmonary/Vascular Injury and Disease Am. J. Respir. Cell Mol. Biol., February 1, 2007; 36(2): 175 - 182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. T. Botros and L. G. Navar Interaction between endogenously produced carbon monoxide and nitric oxide in regulation of renal afferent arterioles Am J Physiol Heart Circ Physiol, December 1, 2006; 291(6): H2772 - H2778. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Stocker and M. A. Perrella Heme Oxygenase-1: A Novel Drug Target for Atherosclerotic Diseases? Circulation, November 14, 2006; 114(20): 2178 - 2189. [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Mingone, S. A. Gupte, J. L. Chow, M. Ahmad, N. G. Abraham, and M. S. Wolin Protoporphyrin IX generation from {delta}-aminolevulinic acid elicits pulmonary artery relaxation and soluble guanylate cyclase activation. Am J Physiol Lung Cell Mol Physiol, September 1, 2006; 291(3): L337 - L344. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Favory, S. Lancel, S. Tissier, D. Mathieu, B. Decoster, and R. Neviere Myocardial Dysfunction and Potential Cardiac Hypoxia in Rats Induced by Carbon Monoxide Inhalation Am. J. Respir. Crit. Care Med., August 1, 2006; 174(3): 320 - 325. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Andresen, N. I. Shafi, W. Durante, and R. M. Bryan Jr. Effects of carbon monoxide and heme oxygenase inhibitors in cerebral vessels of rats and mice Am J Physiol Heart Circ Physiol, July 1, 2006; 291(1): H223 - H230. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. W. Ryter, J. Alam, and A. M. K. Choi Heme Oxygenase-1/Carbon Monoxide: From Basic Science to Therapeutic Applications Physiol Rev, April 1, 2006; 86(2): 583 - 650. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. W. Leffler, H. Parfenova, J. H. Jaggar, and R. Wang Carbon monoxide and hydrogen sulfide: gaseous messengers in cerebrovascular circulation J Appl Physiol, March 1, 2006; 100(3): 1065 - 1076. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. K. Johnson, R. A. Johnson, W. Durante, K. E. Jackson, B. K. Stevenson, and K. J. Peyton Metabolic syndrome increases endogenous carbon monoxide production to promote hypertension and endothelial dysfunction in obese Zucker rats Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2006; 290(3): R601 - R608. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Rebel, S. Cao, H. Kwansa, S. Dore, E. Bucci, and R. C. Koehler Dependence of acetylcholine and ADP dilation of pial arterioles on heme oxygenase after transfusion of cell-free polymeric hemoglobin Am J Physiol Heart Circ Physiol, March 1, 2006; 290(3): H1027 - H1037. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Raupach, K. Schafer, S. Konstantinides, and S. Andreas Secondhand smoke as an acute threat for the cardiovascular system: a change in paradigm Eur. Heart J., February 2, 2006; 27(4): 386 - 392. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Wu and R. Wang Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications Pharmacol. Rev., December 1, 2005; 57(4): 585 - 630. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Morita Heme Oxygenase and Atherosclerosis Arterioscler. Thromb. Vasc. Biol., September 1, 2005; 25(9): 1786 - 1795. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. J. Teran, R. A. Johnson, B. K. Stevenson, K. J. Peyton, K. E. Jackson, S. D. Appleton, W. Durante, and F. K. Johnson Heme oxygenase-derived carbon monoxide promotes arteriolar endothelial dysfunction and contributes to salt-induced hypertension in Dahl salt-sensitive rats Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2005; 288(3): R615 - R622. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. K. Johnson, W. Durante, K. J. Peyton, and R. A. Johnson Heme oxygenase-mediated endothelial dysfunction in DOCA-salt, but not in spontaneously hypertensive, rat arterioles Am J Physiol Heart Circ Physiol, May 1, 2004; 286(5): H1681 - H1687. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Rodriguez, B. D. Lamon, W. Gong, R. Kemp, and A. Nasjletti Nitric Oxide Synthesis Inhibition Promotes Renal Production of Carbon Monoxide Hypertension, February 1, 2004; 43(2): 347 - 351. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Marks, J. F. Brien, and K. Nakatsu What role does the heme-- heme oxygenase--carbon monoxide system play in vasoregulation? Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2003; 285(3): R522 - R523. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
