AJP - Regu AJP: Lung Cellular and Molecular Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 285: R536-R541, 2003. First published April 3, 2003; doi:10.1152/ajpregu.00624.2002
0363-6119/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
285/3/R536    most recent
00624.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (37)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Johnson, F. K.
Right arrow Articles by Johnson, R. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Johnson, F. K.
Right arrow Articles by Johnson, R. A.

LOCAL CONTROL OF CIRCULATION

Carbon monoxide promotes endothelium-dependent constriction of isolated gracilis muscle arterioles

Fruzsina K. Johnson and Robert A. Johnson

Department of Physiology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112

Submitted 8 October 2002 ; accepted in final form 2 April 2003

Vascular tissues express heme oxygenase, which metabolizes heme to form carbon monoxide (CO). CO promotes relaxation of vascular smooth muscle but also inhibits nitric oxide (NO) formation. This study examines the hypothesis that CO promotes endothelium- and NO synthase-dependent vasoconstriction of isolated arterioles. Studies were conducted on pressurized first-order gracilis muscle arterioles isolated from anesthetized male Sprague-Dawley rats. Exogenous CO, as well as a heme precursor, {delta}-aminolevulinic acid ({delta}-ALA), constricted arterioles with intact endothelium pretreated with phenylephrine; these effects were abolished by removal of the endothelium. CO- and {delta}-ALA-induced vasoconstrictions were converted to dilations by pretreatment with an inhibitor of NO synthase, N{omega}-nitro-L-arginine methyl ester, or with N{omega}-nitro-L-arginine methyl ester and an NO donor, sodium nitroprusside. Furthermore, CO-induced vasoconstriction was prevented by pretreatment with the NO synthase substrate L-arginine. This study shows that exogenous, as well as endogenously formed, CO can promote endothelium-dependent vasoconstriction in isolated gracilis muscle arterioles. Because CO-induced vasoconstriction is abolished by NO synthase blockade and by L-arginine, CO most likely promotes endothelium-dependent vasoconstriction by inhibiting endothelial NO formation.

heme oxygenase; nitric oxide; vascular tone; {delta}-aminolevulinic acid


Address for reprint requests and other correspondence: F. K. Johnson, Dept. of Physiology, Tulane University Health Sciences Center, 1430 Tulane Ave., SL39, New Orleans, LA 70112 (E-mail: Fruzsi123{at}aol.com).




This article has been cited by other articles:


Home page
 Circ. Res.Home page
B. D. Lamon, F. F. Zhang, N. Puri, S. V. Brodsky, M. S. Goligorsky, and A. Nasjletti
Dual Pathways of Carbon Monoxide-Mediated Vasoregulation: Modulation by Redox Mechanisms
Circ. Res., October 9, 2009; 105(8): 775 - 783.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. A. Dombkowski, N. L. Whitfield, R. Motterlini, Y. Gao, and K. R. Olson
Effects of carbon monoxide on trout and lamprey vessels
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2009; 296(1): R141 - R149.
[Abstract] [Full Text] [PDF]

Home page
 ICVTSHome page
P. E. Achouh, S. Simonet, J.-N. Fabiani, and T. J. Verbeuren
Carbon monoxide induces relaxation of human internal thoracic and radial arterial grafts
Interactive CardioVascular and Thoracic Surgery, December 1, 2008; 7(6): 959 - 962.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
G. L. Volti, L. Vanella, D. Gazzolo, and F. Galvano
Carbon monoxide: vasoconstrictor or vasodilator? That's the question
Am J Physiol Renal Physiol, October 1, 2008; 295(4): F901 - F903.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
K. A. Nath, L. V. d'Uscio, J. P. Juncos, A. J. Croatt, M. C. Manriquez, S. T. Pittock, and Z. S. Katusic
An analysis of the DOCA-salt model of hypertension in HO-1-/- mice and the Gunn rat
Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H333 - H342.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
S. W. Ryter, D. Morse, and A. M. K. Choi
Carbon Monoxide and Bilirubin: Potential Therapies for Pulmonary/Vascular Injury and Disease
Am. J. Respir. Cell Mol. Biol., February 1, 2007; 36(2): 175 - 182.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
F. T. Botros and L. G. Navar
Interaction between endogenously produced carbon monoxide and nitric oxide in regulation of renal afferent arterioles
Am J Physiol Heart Circ Physiol, December 1, 2006; 291(6): H2772 - H2778.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
R. Stocker and M. A. Perrella
Heme Oxygenase-1: A Novel Drug Target for Atherosclerotic Diseases?
Circulation, November 14, 2006; 114(20): 2178 - 2189.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C. J. Mingone, S. A. Gupte, J. L. Chow, M. Ahmad, N. G. Abraham, and M. S. Wolin
Protoporphyrin IX generation from {delta}-aminolevulinic acid elicits pulmonary artery relaxation and soluble guanylate cyclase activation.
Am J Physiol Lung Cell Mol Physiol, September 1, 2006; 291(3): L337 - L344.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. Favory, S. Lancel, S. Tissier, D. Mathieu, B. Decoster, and R. Neviere
Myocardial Dysfunction and Potential Cardiac Hypoxia in Rats Induced by Carbon Monoxide Inhalation
Am. J. Respir. Crit. Care Med., August 1, 2006; 174(3): 320 - 325.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. J. Andresen, N. I. Shafi, W. Durante, and R. M. Bryan Jr.
Effects of carbon monoxide and heme oxygenase inhibitors in cerebral vessels of rats and mice
Am J Physiol Heart Circ Physiol, July 1, 2006; 291(1): H223 - H230.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
S. W. Ryter, J. Alam, and A. M. K. Choi
Heme Oxygenase-1/Carbon Monoxide: From Basic Science to Therapeutic Applications
Physiol Rev, April 1, 2006; 86(2): 583 - 650.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. W. Leffler, H. Parfenova, J. H. Jaggar, and R. Wang
Carbon monoxide and hydrogen sulfide: gaseous messengers in cerebrovascular circulation
J Appl Physiol, March 1, 2006; 100(3): 1065 - 1076.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
F. K. Johnson, R. A. Johnson, W. Durante, K. E. Jackson, B. K. Stevenson, and K. J. Peyton
Metabolic syndrome increases endogenous carbon monoxide production to promote hypertension and endothelial dysfunction in obese Zucker rats
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2006; 290(3): R601 - R608.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. Rebel, S. Cao, H. Kwansa, S. Dore, E. Bucci, and R. C. Koehler
Dependence of acetylcholine and ADP dilation of pial arterioles on heme oxygenase after transfusion of cell-free polymeric hemoglobin
Am J Physiol Heart Circ Physiol, March 1, 2006; 290(3): H1027 - H1037.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
T. Raupach, K. Schafer, S. Konstantinides, and S. Andreas
Secondhand smoke as an acute threat for the cardiovascular system: a change in paradigm
Eur. Heart J., February 2, 2006; 27(4): 386 - 392.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
L. Wu and R. Wang
Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications
Pharmacol. Rev., December 1, 2005; 57(4): 585 - 630.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
T. Morita
Heme Oxygenase and Atherosclerosis
Arterioscler Thromb Vasc Biol, September 1, 2005; 25(9): 1786 - 1795.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
F. J. Teran, R. A. Johnson, B. K. Stevenson, K. J. Peyton, K. E. Jackson, S. D. Appleton, W. Durante, and F. K. Johnson
Heme oxygenase-derived carbon monoxide promotes arteriolar endothelial dysfunction and contributes to salt-induced hypertension in Dahl salt-sensitive rats
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2005; 288(3): R615 - R622.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
F. K. Johnson, W. Durante, K. J. Peyton, and R. A. Johnson
Heme oxygenase-mediated endothelial dysfunction in DOCA-salt, but not in spontaneously hypertensive, rat arterioles
Am J Physiol Heart Circ Physiol, May 1, 2004; 286(5): H1681 - H1687.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
F. Rodriguez, B. D. Lamon, W. Gong, R. Kemp, and A. Nasjletti
Nitric Oxide Synthesis Inhibition Promotes Renal Production of Carbon Monoxide
Hypertension, February 1, 2004; 43(2): 347 - 351.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
G. S. Marks, J. F. Brien, and K. Nakatsu
What role does the heme-- heme oxygenase--carbon monoxide system play in vasoregulation?
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2003; 285(3): R522 - R523.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2003 by the American Physiological Society.