| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
LOCAL CONTROL OF CIRCULATION
Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7545
Submitted 17 December 2002 ; accepted in final form 29 May 2003
We investigated dynamic characteristics of renal blood flow (RBF)
autoregulation and relative contribution of underlying mechanisms within the
autoregulatory pressure range in rats. Renal arterial pressure (RAP) was
reduced by suprarenal aortic constriction for 60 s and then rapidly released.
Changes in renal vascular resistance (RVR) were assessed following rapid step
reduction and RAP rise. In response to rise, RVR initially fell 5-10% and
subsequently increased 
20%, reflecting 93% autoregulatory efficiency
(AE). Within the initial 7-9 s, RVR rose to 55% of total response providing
37% AE, reaching maximum speed at 2.2 s. A secondary RVR increase began at 7-9
s and reached maximum speed at 10-15 s. Response times suggest that the
initial RVR reflects the myogenic response and the secondary tubuloglomerular
feedback (TGF). During TGF inhibition by furosemide, AE was 64%. The initial
RVR rise was accelerated and enhanced, providing 49% AE, but it represented
only 88% of total. The remaining 12% indicates a third regulatory component.
The latter contributed up to 50% when the RAP increase began below the
autoregulatory range. TGF augmentation by acetazolamide affected neither AE
nor relative myogenic contribution. Diltiazem infusion markedly inhibited AE
and the primary and secondary RVR increases but left a slow component. In
response to RAP reduction, initial vasodilation constituted 73% of total
response but was not affected by furosemide. The third component's
contribution was 9%. Therefore, RBF autoregulation is primarily due to
myogenic response and TGF, contributing 55% and 33-45% in response to RAP rise
and 73% and 18-27% to RAP reduction. The data imply interaction between TGF
and myogenic response affecting strength and speed of myogenic response during
RAP rises. The data suggest a third regulatory system contributing <12%
normally but up to 50% at low RAP; its nature awaits further
investigation.
renal circulation; afferent arteriole; glomerular arterioles; myogenic mechanism; tubuloglomerular feedback; vascular smooth muscle cells; macula densa cells; calcium channel blocker; furosemide; acetazolamide
This article has been cited by other articles:
|
|
 |
|
  A. Just, L. Kurtz, C. de Wit, C. Wagner, A. Kurtz, and W. J. Arendshorst Connexin 40 Mediates the Tubuloglomerular Feedback Contribution to Renal Blood Flow Autoregulation J. Am. Soc. Nephrol., July 1, 2009; 20(7): 1577 - 1585. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Siu, B. Sung, W. A. Cupples, L. C. Moore, and K. H. Chon Detection of low-frequency oscillations in renal blood flow Am J Physiol Renal Physiol, July 1, 2009; 297(1): F155 - F162. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Seeliger, T. Wronski, M. Ladwig, L. Dobrowolski, T. Vogel, M. Godes, P. B. Persson, and B. Flemming The renin-angiotensin system and the third mechanism of renal blood flow autoregulation Am J Physiol Renal Physiol, June 1, 2009; 296(6): F1334 - F1345. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. M. Stauss, K. R. Rarick, R. J. Deklotz, and D. D. Sheriff Frequency response characteristics of whole body autoregulation of blood flow in rats Am J Physiol Heart Circ Physiol, May 1, 2009; 296(5): H1607 - H1616. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Ren, M. A. D'Ambrosio, J. L. Garvin, H. Wang, and O. A. Carretero Possible Mediators of Connecting Tubule Glomerular Feedback Hypertension, February 1, 2009; 53(2): 319 - 323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. W. Inscho Mysteries of Renal Autoregulation Hypertension, February 1, 2009; 53(2): 299 - 306. [Full Text] [PDF]
|
|
|
|
|
|
T. D. Bell, G. F. DiBona, R. Biemiller, and M. W. Brands Continuously measured renal blood flow does not increase in diabetes if nitric oxide synthesis is blocked Am J Physiol Renal Physiol, November 1, 2008; 295(5): F1449 - F1456. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. H. Chon, Y. Zhong, L. C. Moore, N. H. Holstein-Rathlou, and W. A. Cupples Analysis of nonstationarity in renal autoregulation mechanisms using time-varying transfer and coherence functions Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2008; 295(3): R821 - R828. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Kleinstreuer, T. David, M. J. Plank, and Z. Endre Dynamic myogenic autoregulation in the rat kidney: a whole-organ model Am J Physiol Renal Physiol, June 1, 2008; 294(6): F1453 - F1464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Takenaka, T. Inoue, Y. Kanno, H. Okada, C. E. Hill, and H. Suzuki Connexins 37 and 40 transduce purinergic signals mediating renal autoregulation Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2008; 294(1): R1 - R11. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Seeliger, B. Flemming, T. Wronski, M. Ladwig, K. Arakelyan, M. Godes, M. Mockel, and P. B. Persson Viscosity of Contrast Media Perturbs Renal Hemodynamics J. Am. Soc. Nephrol., November 1, 2007; 18(11): 2912 - 2920. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Just and W. J. Arendshorst A novel mechanism of renal blood flow autoregulation and the autoregulatory role of A1 adenosine receptors in mice Am J Physiol Renal Physiol, November 1, 2007; 293(5): F1489 - F1500. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Balasubramanian, A. Ahmed, C.-M. Lo, J. S. K. Sham, and K.-P. Yip Integrin-mediated mechanotransduction in renal vascular smooth muscle cells: activation of calcium sparks Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2007; 293(4): R1586 - R1594. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. A. Cupples and B. Braam Assessment of renal autoregulation Am J Physiol Renal Physiol, April 1, 2007; 292(4): F1105 - F1123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Langager, B. E. Hammerberg, D. L. Rotella, and H. M. Stauss Very low-frequency blood pressure variability depends on voltage-gated L-type Ca2+ channels in conscious rats Am J Physiol Heart Circ Physiol, March 1, 2007; 292(3): H1321 - H1327. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Just Mechanisms of renal blood flow autoregulation: dynamics and contributions Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R1 - R17. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Kolb, D. L. Rotella, and H. M. Stauss Frequency response characteristics of cerebral blood flow autoregulation in rats Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H432 - H438. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Peti-Peterdi Calcium wave of tubuloglomerular feedback Am J Physiol Renal Physiol, August 1, 2006; 291(2): F473 - F480. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Loutzenhiser, K. Griffin, G. Williamson, and A. Bidani Renal autoregulation: new perspectives regarding the protective and regulatory roles of the underlying mechanisms Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2006; 290(5): R1153 - R1167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Takenaka, H. Okada, Y. Kanno, T. Inoue, M. Ryuzaki, H. Nakamoto, H. Kawachi, F. Shimizu, and H. Suzuki Exogenous 5'-nucleotidase improves glomerular autoregulation in Thy-1 nephritic rats Am J Physiol Renal Physiol, April 1, 2006; 290(4): F844 - F853. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Just and W. J. Arendshorst Nitric oxide blunts myogenic autoregulation in rat renal but not skeletal muscle circulation via tubuloglomerular feedback J. Physiol., December 15, 2005; 569(3): 959 - 974. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
