HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 285/4/R800    most recent 00014.2003v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (15) Citing Articles via Google Scholar Google Scholar Articles by Dahly, E. M. Articles by Ney, D. M. Search for Related Content PubMed PubMed Citation Articles by Dahly, E. M. Articles by Ney, D. M.

DEVELOPMENT AND TISSUE PLASTICITY

IGF-I augments resection-induced mucosal hyperplasia by altering enterocyte kinetics

¹Department of Nutritional Sciences, University of Wisconsin-Madison, Madison 53706; and ²Department of Pathology and Laboratory Medicine, University of Wisconsin Hospitals and Clinics, Madison, Wisconsin 53792

Submitted 10 January 2003 ; accepted in final form 19 May 2003

Our objective was to determine if exogenous insulin-like growth factor-I (IGF-I) augments the adaptive growth response to mid small bowel resection in association with changes in enterocyte kinetics. We determined structural adaptation and concomitant changes in enterocyte proliferation, apoptosis, and migration of the jejunum in growing, parenterally fed rats after mid small bowel resection or small bowel transection, and treatment with IGF-I or vehicle. IGF-I treatment in resected rats significantly increased jejunal mucosal mass by 20% and mucosal concentrations of protein and DNA by 36 and 33%, respectively, above the response to resection alone. The enhancement of resection-induced adaptive growth and cellularity by IGF-I reflected an increase in enterocyte proliferation, an expansion of the proliferative compartment in the crypt, and no further decrease in enterocyte apoptosis or increase in enterocyte migration beyond the effects of resection. The ability of IGF-I to augment the mucosal hyperplasia stimulated by the endogenous response to resection substantiates the role of IGF-I as an intestinal mitogen that promotes tissue regeneration.

enterocyte proliferation and apoptosis; insulin-like growth factor-I; intestinal adaptation; bowel resection; total parenteral nutrition

This article has been cited by other articles:

				X. Liu, S. G. Murali, J. J. Holst, and D. M. Ney Whey protein potentiates the intestinotrophic action of glucagon-like peptide-2 in parenterally fed rats Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2009; 297(5): R1554 - R1562. [Abstract] [Full Text] [PDF]

				A. P. Garrison, C. M. Dekaney, D. C. von Allmen, P. K. Lund, S. J. Henning, and M. A. Helmrath Early but not late administration of glucagon-like peptide-2 following ileo-cecal resection augments putative intestinal stem cell expansion Am J Physiol Gastrointest Liver Physiol, March 1, 2009; 296(3): G643 - G650. [Abstract] [Full Text] [PDF]

				C. P. A. Ivory, L. E. Wallace, D.-M. McCafferty, and D. L. Sigalet Interleukin-10-independent anti-inflammatory actions of glucagon-like peptide 2 Am J Physiol Gastrointest Liver Physiol, December 1, 2008; 295(6): G1202 - G1210. [Abstract] [Full Text] [PDF]

				X. Liu, S. G. Murali, J. J. Holst, and D. M. Ney Enteral nutrients potentiate the intestinotrophic action of glucagon-like peptide-2 in association with increased insulin-like growth factor-I responses in rats Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2008; 295(6): R1794 - R1802. [Abstract] [Full Text] [PDF]

				D. L. Sigalet, L. E. Wallace, J. J. Holst, G. R. Martin, T. Kaji, H. Tanaka, and K. A. Sharkey Enteric neural pathways mediate the anti-inflammatory actions of glucagon-like peptide 2 Am J Physiol Gastrointest Liver Physiol, July 1, 2007; 293(1): G211 - G221. [Abstract] [Full Text] [PDF]

				L. Wang, Y. Tang, D. C. Rubin, and M. S. Levin Chronically administered retinoic acid has trophic effects in the rat small intestine and promotes adaptation in a resection model of short bowel syndrome Am J Physiol Gastrointest Liver Physiol, June 1, 2007; 292(6): G1559 - G1569. [Abstract] [Full Text] [PDF]

				J. Tian, N. Washizawa, L. H. Gu, M. S. Levin, L. Wang, D. C. Rubin, S. Mwangi, S. Srinivasan, D. P. Jones, and T. R. Ziegler Local Glutathione Redox Status Does Not Regulate Ileal Mucosal Growth after Massive Small Bowel Resection in Rats J. Nutr., February 1, 2007; 137(2): 320 - 325. [Abstract] [Full Text] [PDF]

				C. Z. Michaylira, J. G. Simmons, N. M. Ramocki, B. P. Scull, K. K. McNaughton, C. R. Fuller, and P. K. Lund Suppressor of cytokine signaling-2 limits intestinal growth and enterotrophic actions of IGF-I in vivo Am J Physiol Gastrointest Liver Physiol, September 1, 2006; 291(3): G472 - G481. [Abstract] [Full Text] [PDF]

				P. Rittler, B. Schiefer, H. Demmelmair, B. Koletzko, M. Vogeser, D. H. Alpers, K.-W. Jauch, and W. H. Hartl The Effect of Hyperglycemic Hyperinsulinemia on Small-Intestinal Mucosal Protein Synthesis in Patients After Surgical Stress JPEN J Parenter Enteral Nutr, March 1, 2006; 30(2): 97 - 107. [Abstract] [Full Text] [PDF]