HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (13) Citing Articles via Google Scholar Google Scholar Articles by Mantella, R. C. Articles by Amico, J. A. Search for Related Content PubMed PubMed Citation Articles by Mantella, R. C. Articles by Amico, J. A.

CALL FOR PAPERS
Peptides that Regulate Food Intake

Cholecystokinin and D-fenfluramine inhibit food intake in oxytocin-deficient mice

Departments of ¹Pharmaceutical Sciences, ³Medicine, and ²Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15261

Submitted 25 June 2002 ; accepted in final form 2 May 2003

ABSTRACT

Results from previous studies indicate that oxytocin (OT)-containing neural pathways are activated in laboratory rats after systemic administration of CCK or D-fenfluramine and that centrally released OT may participate in the anorexigenic effects of these treatments. To explore the relationship between feeding behavior and OT function, the effects of CCK and D-fenfluramine on feeding and central c-Fos expression were compared in wild-type (OT+/+) and OT-deficient mice (OT-/-) of C57BL/6 background. Male OT+/+ and OT-/- mice were administered saline or CCK (1, 3, or 10 µg/kg ip) after overnight food deprivation. Saline-treated OT+/+ and OT-/- mice consumed equivalent amounts of food after an overnight fast. CCK inhibited deprivation-induced food intake in a dose-dependent manner to a similar extent in both genotypes. CCK treatment also induced similar hindbrain and forebrain patterns of increased c-Fos expression in mice of both genotypes. After treatment with D-fenfluramine (10 mg/kg ip), both OT+/+ and OT-/- mice consumed significantly less food than untreated controls, with no difference between genotypes. We conclude that OT signaling pathways are unnecessary for the anorexigenic effects of systemically administered CCK and D-fenfluramine in C57BL/6 mice.

c-Fos; hypothalamus; dorsal vagal complex; anorexia

This article has been cited by other articles:

				J. A. Miedlar, L. Rinaman, R. R. Vollmer, and J. A. Amico Oxytocin gene deletion mice overconsume palatable sucrose solution but not palatable lipid emulsions Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1063 - R1068. [Abstract] [Full Text] [PDF]

				A. Sclafani, L. Rinaman, R. R. Vollmer, and J. A. Amico Oxytocin knockout mice demonstrate enhanced intake of sweet and nonsweet carbohydrate solutions Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2007; 292(5): R1828 - R1833. [Abstract] [Full Text] [PDF]

				J. A. Amico, R. R. Vollmer, H.-m. Cai, J. A. Miedlar, and L. Rinaman Enhanced initial and sustained intake of sucrose solution in mice with an oxytocin gene deletion Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2005; 289(6): R1798 - R1806. [Abstract] [Full Text] [PDF]

				W. A. Cupples Physiological regulation of food intake Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2005; 288(6): R1438 - R1443. [Full Text] [PDF]

				L. Rinaman, R. R. Vollmer, J. Karam, D. Phillips, X. Li, and J. A. Amico Dehydration anorexia is attenuated in oxytocin-deficient mice Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2005; 288(6): R1791 - R1799. [Abstract] [Full Text] [PDF]

				R. C. Mantella, R. R. Vollmer, L. Rinaman, X. Li, and J. A. Amico Enhanced corticosterone concentrations and attenuated Fos expression in the medial amygdala of female oxytocin knockout mice exposed to psychogenic stress Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2004; 287(6): R1494 - R1504. [Abstract] [Full Text] [PDF]

				J. E. Blevins, M. W. Schwartz, and D. G. Baskin Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2004; 287(1): R87 - R96. [Abstract] [Full Text] [PDF]