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This Article Full Text Full Text (PDF) All Versions of this Article: 285/5/R1098    most recent 00731.2002v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (6) Citing Articles via Google Scholar Google Scholar Articles by van Anholt, R. D. Articles by Bonga, S. E. W. Search for Related Content PubMed PubMed Citation Articles by van Anholt, R. D. Articles by Bonga, S. E. W.

COMPLEX FUNCTION OF THE CENTRAL NERVOUS SYSTEM, SLEEP AND LOCOMOTION

Effects of acetylsalicylic acid treatment on thyroid hormones, prolactins, and the stress response of tilapia (Oreochromis mossambicus)

¹Department of Animal Ecology and Ecophysiology, Faculty of Science, University of Nijmegen, 6525 ED Nijmegen, The Netherlands; and ²Department of Larval Rearing, The National Center for Mariculture, Eilat 88112, Israel

Submitted 2 December 2002 ; accepted in final form 2 July 2003

The cyclooxygenase (COX) pathway converts arachidonic acid (ArA) into prostaglandins (PGs), which interact with the stress response in mammals and possibly in fish as well. Acetylsalicylic acid (ASA) is a COX inhibitor and was used to characterize the effects of PGs on the release of several hormones and the stress response of tilapia (Oreochromis mossambicus). Plasma PGE₂ was significantly reduced at 100 mg ASA/kg body wt, and both basal PGE₂ and cortisol levels correlated negatively with plasma salicylate. Basal plasma 3,5,3'-triiodothyronine (T₃) was reduced by ASA treatment, whereas prolactin (PRL)₁₈₈ increased at 100 mg ASA/kg body wt. ASA depressed the cortisol response to the mild stress of 5 min of net confinement. As expected, glucose and lactate were elevated in the stressed control fish, but the responses were blunted by ASA treatment. Gill Na⁺-K⁺-ATPase activity was not affected by ASA. Plasma osmolarity increased after confinement in all treatments, whereas sodium only increased at the high ASA dose. This is the first time ASA has been administered to fish in vivo, and the altered hormone release and the inhibition of the acute stress response indicated the involvement of PGs in these processes.

arachidonic acid; cortisol; eicosanoids; prostaglandins

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