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Am J Physiol Regul Integr Comp Physiol 285: R1203-R1211, 2003; doi:10.1152/ajpregu.00098.2003
0363-6119/03 $5.00
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THIRST AND VOLUME, ELECTROLYTE HOMEOSTASIS

Increased thirst and vasopressin secretion after myocardial infarction in rats

H. R. De Smet,1 M. F. Menadue,2 J. R. Oliver,2 and P. A. Phillips1

1Department of Medicine, Flinders University of South Australia; and 2Endrocrinology Unit, Flinders Medical Center, Bedford Park, South Australia 5042, Australia

Submitted 28 February 2003 ; accepted in final form 15 July 2003

Impaired regulation of salt and water balance in left ventricular dysfunction and heart failure can lead to pulmonary and peripheral edema and hyponatremia. Previous studies of disordered water regulation in heart failure have used models of low cardiac output with normal cardiac function (e.g., inferior vena cava ligation). We investigated thirst and vasopressin (AVP) secretion in a rat myocardial infarction model of chronic left ventricular dysfunction/heart failure in response to a 24-h water deprivation period. Thirst (implied from water drunk), hematocrit, plasma renin activity, and plasma AVP concentrations increased with water deprivation vs. ad libitum water access. Thirst and plasma AVP concentrations were significantly positively correlated with infarct size after 24-h water deprivation but not under ad libitum water access conditions. The mechanism by which this occurs is unclear but could involve increased osmoreceptor sensitivity, altered stimulation of baroreceptors, the renin-angiotensin system, or altered central neural control.

heart failure; atrial natriuretic peptide


Address for reprint requests and other correspondence: P. A. Phillips, Dept. of Medicine, Flinders Medical Centre, Bedford Park, South Australia 5042, Australia (E-mail: paddy.phillips{at}flinders.edu.au).


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AJP - Regu 2006 291: R860. [Full Text]  





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