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This Article Full Text Full Text (PDF) All Versions of this Article: 286/1/R94    most recent 00648.2002v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (11) Citing Articles via Google Scholar Google Scholar Articles by Ruan, Z. Articles by Nishio, M. Search for Related Content PubMed PubMed Citation Articles by Ruan, Z. Articles by Nishio, M.

INFLAMMATION, CYTOKINES, AND TEMPERATURE REGULATION

NO, but not CO, attenuates anaphylaxis-induced postsinusoidal contraction and congestion in guinea pig liver

Division 2, Departments of ¹Physiology, ³Anesthesiology, and ⁴Pharmacology, Kanazawa Medical University, Uchinada 920-0293; and ²First Department of Medicine, Shinshu University School of Medicine, Matsumoto 390-8621, Japan

Submitted 21 October 2002 ; accepted in final form 26 September 2003

The pathophysiology of the hepatic vascular response to anaphylaxis in guinea pig is not known. We studied effects of anaphylaxis on hepatic vascular resistances and liver weight in isolated perfused livers derived from guinea pigs sensitized with ovalbumin. We also determined whether nitric oxide (NO) or carbon monoxide (CO) modulates the hepatic anaphylaxis. The livers were perfused portally and recirculatingly at constant flow with diluted blood. With the use of the double-occlusion technique to estimate the hepatic sinusoidal pressure (P_do), portal venous resistance (R_pv) and hepatic venous resistance (R_hv) were calculated. An antigen injection caused venoconstriction characterized by an increase in R_pv greater than R_hv and was accompanied by a large liver weight gain. Pretreatment with the NO synthase inhibitor N^G-nitro-L-arginine methyl ester, but not the heme oxygenase inhibitor zinc protoporphyrin IX, potentiated the antigen-induced venoconstriction by increasing both R_pv and R_hv (2.2- and 1.2-fold increase, respectively). In conclusion, anaphylaxis causes both pre- and postsinusoidal constriction in isolated guinea pig livers. However, the increases in postsinusoidal resistance and P_do cause hepatic congestion. Endogenously produced NO, but not CO, modulates these responses.

hepatic circulation; antigen; double occlusion pressure; hepatic vascular resistance

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