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INFLAMMATION, CYTOKINES, AND TEMPERATURE REGULATION

Effects of moderate exercise and oat -glucan on innate immune function and susceptibility to respiratory infection

¹Department of Exercise Science, Arnold School of Public Health; and the ²Department of Pathology and Microbiology, School of Medicine, University of South Carolina, Columbia, South Carolina 29208

Submitted 2 June 2003 ; accepted in final form 7 October 2003

Both moderate exercise and the soluble oat fiber -glucan can increase immune function and decrease risk of infection, but no information exists on their possible combined effects. This study tested the effects of moderate exercise and oat -glucan on respiratory infection, macrophage antiviral resistance, and natural killer (NK) cell cytotoxicity. Mice were assigned to four groups: exercise and water, exercise and oat -glucan, control water, or control oat -glucan. Oat -glucan was fed in the drinking water for 10 days before intranasal inoculation of herpes simplex virus type 1 (HSV-1) or euthanasia. Exercise consisted of treadmill running (1 h/day) for 6 days. Macrophage resistance to HSV-1 was increased with both exercise and oat -glucan, whereas NK cell cytotoxicity was only increased with exercise. Exercise was also associated with a 45 and 38% decrease in morbidity and mortality, respectively. Mortality was also decreased with oat -glucan, but this effect did not reach statistical significance. No additive effects of exercise and oat -glucan were found. These data confirm a positive effect of both moderate exercise and oat -glucan on immune function, but only moderate exercise was associated with a significant reduction in the risk of upper respiratory tract infection in this model.

macrophage; natural killer cell; viral infection; morbidity; mortality

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