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APPETITE, OBESITY AND METABOLISM

Compensation for an increase in body fat caused by donor transplants into mice

Department of Foods and Nutrition, University of Georgia, Athens 30602; and Department of Biology and Center for Behavioral Neuroscience, Georgia State University, Atlanta, Georgia 30303

Submitted 29 October 2003 ; accepted in final form 23 February 2004

Rodents tend to compensate for experimental obesity in which both adipocyte size and number are increased. In contrast, it was recently reported that Siberian hamsters do not compensate for dorsal subcutaneous transplants of fat, which increase body fat without changing the size of adipocytes. In the first experiment described here we tested whether mice changed the size of their endogenous fat stores 2 or 5 wk after donor fat was added as subcutaneous transplants. Each epididymal fat pad from donor mice was cut in half and placed ventrally in recipient mice, increasing body fat by 10%. After 2 wk, there was no effect of the transplants on the size of endogenous fat depots or the size of adipocytes in epididymal fat depots. There was a substantial decrease in mass and adipocyte size in transplanted fat. Five weeks after surgery the endogenous epididymal and retroperitoneal fat depots of recipient mice were significantly decreased, serum leptin was reduced, and the size of adipocytes in endogenous epididymal fat was significantly reduced, although cell number had not changed. The size of transplanted cells was the same as at 2 wk. In a second experiment, epididymal fat was placed as either dorsal or ventral subcutaneous fat transplants. Five weeks after surgery the endogenous fat depots were decreased in all recipient mice but none of the differences reached statistical significance. These results suggest that mice have mechanisms to maintain total body fat mass that respond to an increase in the number of fat cells present.

body weight; white adipose tissue; cellularity; carcass composition; leptin

This article has been cited by other articles:

				K. Guo, J. Mogen, S. Struzzi, and Y. Zhang Preadipocyte transplantation: an in vivo study of direct leptin signaling on adipocyte morphogenesis and cell size Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2009; 296(5): R1339 - R1347. [Abstract] [Full Text] [PDF]

				E. L. Lacy and T. J. Bartness Effects of white adipose tissue grafts on total body fat and cellularity are dependent on graft type and location Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2005; 289(2): R380 - R388. [Abstract] [Full Text] [PDF]