| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
APPETITE, OBESITY AND METABOLISM
1Molecular and Cellular Biology and Pathobiology Program, Medical University of South Carolina, Charleston, South Carolina 29425; 2Department of Physiology, School of Medicine, University of São Paulo, Ribeirão Preto-SP, 14049-900 Brazil; and 3Department of Biology and Center for Behavioral Neuroscience, Georgia State University, Atlanta, Georgia 30303
Submitted 29 September 2003 ; accepted in final form 17 February 2004
White adipose tissue (WAT) is innervated by the sympathetic nervous system (SNS), and the central origins of this innervation have been demonstrated for inguinal and epididymal WAT (iWAT and eWAT, respectively) using a viral transneuronal tract tracer, the pseudorabies virus (PRV). Although the more established role of this sympathetic innervation of WAT is as a major stimulator of lipid mobilization, this innervation also inhibits WAT fat cell number (FCN); thus, local denervation of WAT leads to marked increases in WAT mass and FCN. The purpose of this study was to extend our understanding of the SNS regulation of FCN using neuroanatomical and functional analyses. Therefore, we injected PRV into retroperitoneal WAT (rWAT) to compare the SNS outflow to this pad from what already is known for iWAT and eWAT. In addition, we tested the ability of local unilateral denervation of rWAT or iWAT to promote increases in WAT mass and FCN vs. their contralateral neurally intact counterparts. Although the overall pattern of innervation was more similar than different for rWAT vs. iWAT or eWAT, its SNS outflow appeared to involve more neurons in the suprachiasmatic and solitary tract nuclei. Denervation produced significant increases in WAT mass and FCN for both iWAT and rWAT, but FCN was increased significantly more in iWAT than in rWAT. These data suggest differences in origins of the sympathetic outflow to WAT and functional differences in the WAT SNS innervation that could contribute to the differential propensity for fat cell proliferation across WAT depots in vivo.
body fat; cellularity; hyperplasia; pseudorabies virus; tract tracing; white fat
This article has been cited by other articles:
|
|
 |
|
  M. J. Dailey and T. J. Bartness Appetitive and consummatory ingestive behaviors stimulated by PVH and perifornical area NPY injections Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2009; 296(4): R877 - R892. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Keen-Rhinehart and T. J. Bartness Leptin inhibits food-deprivation-induced increases in food intake and food hoarding Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2008; 295(6): R1737 - R1746. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. K. Song, C. H. Vaughan, E. Keen-Rhinehart, R. B. S. Harris, D. Richard, and T. J. Bartness Melanocortin-4 receptor mRNA expressed in sympathetic outflow neurons to brown adipose tissue: neuroanatomical and functional evidence Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2008; 295(2): R417 - R428. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Yang, H. Guan, E. Arany, D. J. Hill, and X. Cao Neuropeptide Y is produced in visceral adipose tissue and promotes proliferation of adipocyte precursor cells via the Y1 receptor FASEB J, July 1, 2008; 22(7): 2452 - 2464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. A. Brito, M. N. Brito, and T. J. Bartness Differential sympathetic drive to adipose tissues after food deprivation, cold exposure or glucoprivation Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2008; 294(5): R1445 - R1452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Leitner and T. J. Bartness Food deprivation-induced changes in body fat mobilization after neonatal monosodium glutamate treatment Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2008; 294(3): R775 - R783. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Dailey and T. J. Bartness Fat pad-specific effects of lipectomy on foraging, food hoarding, and food intake Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2008; 294(2): R321 - R328. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Giordano, C. Kay Song, R. R. Bowers, J. Christopher Ehlen, A. Frontini, S. Cinti, and T. J. Bartness Reply to Kreier and Buijs: no sympathy for the claim of parasympathetic innervation of white adipose tissue Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R550 - R552. [Full Text] [PDF]
|
|
|
|
|
|
E. Keen-Rhinehart and T. J. Bartness NPY Y1 receptor is involved in ghrelin- and fasting-induced increases in foraging, food hoarding, and food intake Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2007; 292(4): R1728 - R1737. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Foster and T. J. Bartness Sympathetic but not sensory denervation stimulates white adipocyte proliferation Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2006; 291(6): R1630 - R1637. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Giordano, C. K. Song, R. R. Bowers, J. C. Ehlen, A. Frontini, S. Cinti, and T. J. Bartness White adipose tissue lacks significant vagal innervation and immunohistochemical evidence of parasympathetic innervation Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2006; 291(5): R1243 - R1255. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Wagoner, D. B. Hausman, and R. B. S. Harris Direct and indirect effects of leptin on preadipocyte proliferation and differentiation Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2006; 290(6): R1557 - R1564. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. K. Song, R. M. Jackson, R. B. S. Harris, D. Richard, and T. J. Bartness Melanocortin-4 receptor mRNA is expressed in sympathetic nervous system outflow neurons to white adipose tissue Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2005; 289(5): R1467 - R1476. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. Lacy and T. J. Bartness Effects of white adipose tissue grafts on total body fat and cellularity are dependent on graft type and location Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2005; 289(2): R380 - R388. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Shi and T. J. Bartness White adipose tissue sensory nerve denervation mimics lipectomy-induced compensatory increases in adiposity Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2005; 289(2): R514 - R520. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Bullo, M. R. Peeraully, and P. Trayhurn Stimulation of NGF expression and secretion in 3T3-L1 adipocytes by prostaglandins PGD2, PGJ2, and {Delta}12-PGJ2 Am J Physiol Endocrinol Metab, July 1, 2005; 289(1): E62 - E67. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Day, E. Keen-Rhinehart, and T. J. Bartness Role of NPY and its receptor subtypes in foraging, food hoarding, and food intake by Siberian hamsters Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2005; 289(1): R29 - R36. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Rooks, D. M. Penn, E. Kelso, R. R. Bowers, T. J. Bartness, and R. B. S. Harris Sympathetic denervation does not prevent a reduction in fat pad size of rats or mice treated with peripherally administered leptin Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2005; 289(1): R92 - R102. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. R. Bowers, T. W. Gettys, V. Prpic, R. B. S. Harris, and T. J. Bartness Short photoperiod exposure increases adipocyte sensitivity to noradrenergic stimulation in Siberian hamsters Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2005; 288(5): R1354 - R1360. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Shi, C. K. Song, A. Giordano, S. Cinti, and T. J. Bartness Sensory or sympathetic white adipose tissue denervation differentially affects depot growth and cellularity Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2005; 288(4): R1028 - R1037. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
