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INVITED REVIEW
Department of Pharmacology, Faculty of Medicine, University of Montréal, Montréal, Québec, H3C 3J7 Canada
The cardiac neuronal hierarchy can be represented as a redundant control system made up of spatially distributed cell stations comprising afferent, efferent, and interconnecting neurons. Its peripheral and central neurons are in constant communication with one another such that, for the most part, it behaves as a stochastic control system. Neurons distributed throughout this hierarchy interconnect via specific linkages such that each neuronal cell station is involved in temporally dependent cardio-cardiac reflexes that control overlapping, spatially organized cardiac regions. Its function depends primarily, but not exclusively, on inputs arising from afferent neurons transducing the cardiovascular milieu to directly or indirectly (via interconnecting neurons) modify cardiac motor neurons coordinating regional cardiac behavior. As the function of the whole is greater than that of its individual parts, stable cardiac control occurs most of the time in the absence of direct cause and effect. During altered cardiac status, its redundancy normally represents a stabilizing feature. However, in the presence of regional myocardial ischemia, components within the intrinsic cardiac nervous system undergo pathological change. That, along with any consequent remodeling of the cardiac neuronal hierarchy, alters its spatially and temporally organized reflexes such that populations of neurons, acting in isolation, may destabilize efferent neuronal control of regional cardiac electrical and/or mechanical events.
adrenergic efferent neurons; afferent neurons; autonomic nervous system; cardiac arrhythmias; cardiac force; cardiac rate; cholinergic efferent neurons; heart failure; intrinsic cardiac ganglia; local circuit neurons; memory; middle cervical ganglion; parasympathetic; sympathetic; stellate ganglion; stochastic behavior
ur de Montréal, 5400 boul. Gouin Ouest, Montréal, Québec, H4J 1C5 Canada (E-mail: ja-armour{at}crhsc.umontreal.ca).This article has been cited by other articles:
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