HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 288/1/R80    most recent 00309.2004v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (21) Citing Articles via Google Scholar Google Scholar Articles by Manning, J. Articles by Vehaskari, V. M. Search for Related Content PubMed PubMed Citation Articles by Manning, J. Articles by Vehaskari, V. M.

CALL FOR PAPERS
Fetal Physiological Programming

Postnatal modulation of prenatally programmed hypertension by dietary Na and ACE inhibition

The Research Institute for Children and Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, Louisiana

Submitted 11 May 2004 ; accepted in final form 20 September 2004

Adult hypertension in the rat can be programmed experimentally by changes in intrauterine environment. The offspring typically do not become hypertensive until 6 to 8 wk of age, and recent evidence suggests that renal dysfunction may participate in the pathogenesis. The present study was based on the hypothesis that the window for programming extends to the postnatal period in the rat. Adult hypertension was induced by maternal low-protein diet during the second half of gestation. After being weaned at 3 wk, the offspring were exposed to one of the following regimens for the subsequent 3 wk: 1) low-Na diet, 2) standard Na diet, 3) high-Na diet, and 4) standard Na diet with enalapril. The pups were followed for 10 wk after discontinuation of the treatments. The brief exposure to low-Na diet or enalapril totally prevented the development of hypertension and the effect lasted throughout the observation period. The development of hyperreninemia, present in the standard Na group at 16 wk of age, was abolished in the low-Na and enalapril groups. Conversely, 3-wk exposure to high-Na diet increased the severity of the later hypertension and did not prevent the hyperreninemia. The findings suggest that there is a period of susceptibility during which prenatally programmed hypertension can be modulated postnatally, possibly coinciding with a critical stage in renal maturation.

fetal origins of adult disease; kidney ontogeny; renin-angiotensin system; aldosterone

This article has been cited by other articles:

				A. Dagan, S. Habib, J. Gattineni, V. Dwarakanath, and M. Baum Prenatal programming of rat thick ascending limb chloride transport by low-protein diet and dexamethasone Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2009; 297(1): R93 - R99. [Abstract] [Full Text] [PDF]

				A. Dagan, H. M. Kwon, V. Dwarakanath, and M. Baum Effect of renal denervation on prenatal programming of hypertension and renal tubular transporter abundance Am J Physiol Renal Physiol, July 1, 2008; 295(1): F29 - F34. [Abstract] [Full Text] [PDF]

				V. M. Vehaskari Programming of hypertension: the nervous kidney Am J Physiol Renal Physiol, July 1, 2008; 295(1): F27 - F28. [Full Text] [PDF]

				R. Rexhepaj, K. M. Boini, D. Y. Huang, K. Amann, F. Artunc, K. Wang, J. J. Brosens, D. Kuhl, and F. Lang Role of maternal glucocorticoid inducible kinase SGK1 in fetal programming of blood pressure in response to prenatal diet Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2008; 294(6): R2008 - R2013. [Abstract] [Full Text] [PDF]

				D. Grigore, N. B. Ojeda, E. B. Robertson, A. S. Dawson, C. A. Huffman, E. A. Bourassa, R. C. Speth, K. B. Brosnihan, and B. T. Alexander Placental insufficiency results in temporal alterations in the renin angiotensin system in male hypertensive growth restricted offspring Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2007; 293(2): R804 - R811. [Abstract] [Full Text] [PDF]

				A. Dagan, J. Gattineni, V. Cook, and M. Baum Prenatal programming of rat proximal tubule Na+/H+ exchanger by dexamethasone Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2007; 292(3): R1230 - R1235. [Abstract] [Full Text] [PDF]

				B. T. Alexander Fetal programming of hypertension Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2006; 290(1): R1 - R10. [Abstract] [Full Text] [PDF]

				J. S. Gilbert, A. L. Lang, A. R. Grant, and M. J. Nijland Maternal nutrient restriction in sheep: hypertension and decreased nephron number in offspring at 9 months of age J. Physiol., May 15, 2005; 565(1): 137 - 147. [Abstract] [Full Text] [PDF]

				J. Schwartz and J. L. Morrison Impact and mechanisms of fetal physiological programming Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2005; 288(1): R11 - R15. [Full Text] [PDF]