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This Article Full Text Full Text (PDF) All Versions of this Article: 288/2/R447    most recent 00275.2004v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (6) Citing Articles via Google Scholar Google Scholar Articles by Tanida, M. Articles by Nagai, K. Search for Related Content PubMed PubMed Citation Articles by Tanida, M. Articles by Nagai, K.

NEUROHUMORAL CONTROL OF CARDIOVASCULAR FUNCTION

Dose-dependent effects of L-carnosine on the renal sympathetic nerve and blood pressure in urethane-anesthetized rats

¹Division of Protein Metabolism, Institute for Protein Research, Osaka University, Osaka; ²Niigata University School of Medicine, Niigata; ³Osaka University Graduate School of Medicine, Osaka; and ⁴Institute for Health Care Science, Suntory Limited, Shimamoto, Osaka, Japan

Submitted 30 April 2004 ; accepted in final form 6 October 2004

The physiological function of L-carnosine (-alanyl-L-histidine) synthesized in mammalian muscles has been unclear. Previously, we observed that intravenous (IV) injection of L-carnosine suppressed renal sympathetic nerve activity (RSNA) in urethane-anesthetized rats, and L-carnosine administered via the diet inhibited the elevation of blood pressure (BP) in deoxycorticosterone acetate salt hypertensive rats. To identify the mechanism, we examined effects of IV or intralateral cerebral ventricular (LCV) injection of various doses of L-carnosine on RSNA and BP in urethane-anesthetized rats. Lower doses (1 µg IV; 0.01 µg LCV) of L-carnosine significantly suppressed RSNA and BP, whereas higher doses (100 µg IV; 10 µg LCV) elevated RSNA and BP. Furthermore, we examined effects of antagonists of histaminergic (H1 and H3) receptors on L-carnosine-induced effects. When peripherally and centrally given, thioperamide, an H3 receptor antagonist, blocked RSNA and BP decreases induced by the lower doses of peripheral L-carnosine, whereas diphenhydramine, an H1 receptor antagonist, inhibited increases induced by the higher doses of peripheral L-carnosine. Moreover, bilateral lesions of the hypothalamic suprachiasmatic nucleus eliminated both effects on RSNA and BP induced by the lower (1 µg) and higher (100 µg) doses of peripheral L-carnosine. These findings suggest that low-dose L-carnosine suppresses and high-dose L-carnosine stimulates RSNA and BP, that the suprachiasmatic nucleus and histaminergic nerve are involved in the activities, and that L-carnosine acts in the brain and possibly other organs.

suprachiasmatic nucleus; histaminergic nerve; autonomic nervous system; hypertension; hypotension

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