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This Article Full Text Full Text (PDF) All Versions of this Article: 288/4/R891    most recent 00680.2004v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via ISI Web of Science (7) Citing Articles via Google Scholar Google Scholar Articles by Pyter, L. M. Articles by Nelson, R. J. Search for Related Content PubMed PubMed Citation Articles by Pyter, L. M. Articles by Nelson, R. J.

ENVIRONMENTAL, EXERCISE AND RESPIRATORY PHYSIOLOGY

Social environment modulates photoperiodic immune and reproductive responses in adult male white-footed mice (Peromyscus leucopus)

Departments of Neuroscience and Psychology, and Institute of Behavioral Medicine Research, Ohio State University, Columbus, Ohio

Submitted 4 October 2004 ; accepted in final form 16 November 2004

Social cues may interact with photoperiod to regulate seasonal adaptations in photoperiod-responsive rodents. Specifically, photoperiod-induced adjustments (e.g., reproduction and immune function) may differ among individuals in heterosexual pairs, same-sex pairs, or isolation. Heterosexual cues may be more influential, based on their potential fitness value, than same-sex cues or no social cues. The present study examined the effects of pair (with a male or female) or individual housing on reproductive and immune responses in male white-footed mice (Peromyscus leucopus) maintained in long or short photoperiods. Female pairing did not affect reproductive responses in short-day males. In long days, however, the presence of a female increased both testosterone concentrations and testes mass compared with individually housed and male-paired mice, respectively. Short-day, individually housed males enhanced delayed-type hypersensitivity (DTH) responses compared with single-housed mice in long days, but all paired groups decreased DTH responses regardless of photoperiod. The lack of enhanced DTH response in male mice paired with females coincided with reduced circulating corticosterone concentrations in both photoperiod treatments. Together, these results suggest that social environment may have important modulatory effects on photoperiod-regulated immune responses in male white-footed mice.

delayed-type hypersensitivity; seasonal; 2,4-dinitro-1-flourobenzene; corticosterone; testosterone