AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 288: R1411-R1416, 2005. First published December 16, 2004; doi:10.1152/ajpregu.00446.2004
0363-6119/05 $8.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
288/5/R1411    most recent
00446.2004v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via ISI Web of Science (2)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jordan, J.
Right arrow Articles by Busjahn, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jordan, J.
Right arrow Articles by Busjahn, A.

APPETITE, OBESITY, DIGESTION, AND METABOLISM

Heritability of free and receptor-bound leptin in normal twins

Jens Jordan,1 Georg Brabant,2 Marina Brinsuk,1 Jens Tank,1 Rüdiger Horn,2 Friedrich C. Luft,1 and Andreas Busjahn3

1Franz Volhard Clinical Research Center, Medical Faculty of the Charité and Helios Klinikum, Berlin, Germany; 2Department of Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany; and 3HealthTwiSt, Berlin, Germany

Submitted 6 July 2004 ; accepted in final form 14 December 2004

Free and receptor-bound leptin may be regulated by different mechanisms. Genes that influence the concentration of these fractions may have an important functional bearing. We determined circulating leptin receptor concentrations, bound as well as free leptin concentrations, and body composition in 24 monozygotic (MZ) and in 22 dizygotic (DZ) twin pairs. Bound leptin and leptin receptor concentrations were inversely correlated with body fat content. Free leptin concentrations were directly correlated with body fat content. The correlations in age- and sex-adjusted free leptin, bound leptin, and leptin receptor concentrations were higher between MZ twins than between DZ twins. Adjusted heritability (h2) estimates were 0.28 for free leptin, 0.73 for bound leptin, and 0.55 for leptin receptor. The genetic correlation with body fat was –0.58 for the leptin receptor, –0.20 for bound leptin, and 0.93 for free leptin. Our data are consistent with a strong genetic influence on leptin receptor and bound leptin and a weaker genetic influence on free leptin concentrations. The same genes that lower bound leptin and leptin receptor concentrations may increase fat mass or vice versa.

twin study; heritability; leptin; bound leptin


Address for reprint requests and other correspondence: Jens Jordan, Franz-Volhard Clinical Research Center, Humboldt Univ. Wiltbergstr. 50, 13125 Berlin, Germany (E-mail: jordan{at}fvk-berlin.de)






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2005 by the American Physiological Society.