HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 288/6/R1468    most recent 00602.2004v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (16) Citing Articles via Google Scholar Google Scholar Articles by Evans, S. A. Articles by Overton, J. M. Search for Related Content PubMed PubMed Citation Articles by Evans, S. A. Articles by Overton, J. M.

CALL FOR PAPERS
Physiological Regulation of Appetite

Long-Evans and Sprague-Dawley rats exhibit divergent responses to refeeding after caloric restriction

Departments of Nutrition, Food, and Exercise Sciences and Program in Neuroscience, Florida State University, Tallahassee, Florida

Submitted 3 September 2004 ; accepted in final form 1 February 2005

Mature male Sprague-Dawley (SD) and Long-Evans (LE) rats were instrumented with telemetry transmitters for measurement of heart rate (HR) and housed in room calorimeters for assessment of food intake and oxygen consumption (O₂) at standard laboratory temperatures (23°C) to examine physiological responses to caloric restriction (CR; 60% of baseline ad libitum calories for 2 wk) and refeeding. Ad libitum controls had stable food intake (84–88 kcal/day) and gained weight at rates of 3–4 g/day. Groups from both strains assigned to CR exhibited similar patterns of weight loss and reductions in O₂ and HR. Upon refeeding, SD rats exhibited a mild, transient hyperphagic response (1 day) accompanied by sustained suppression of O₂ and HR that remained evident 8 days after refeeding. In contrast, LE rats exhibited sustained daily hyperphagia that persisted 8 days after refeeding and was accompanied by a complete restoration of HR and O₂. The lower HR and O₂ observed during refeeding in SD rats were not due to reduced locomotor activity. The results reveal a strain-dependent divergent response to recovery from CR. We conclude that during recovery from CR, homeostatic stimulation of appetite or suppression of energy expenditure may occur selectively to restore body weight.

hyperphagia; thermogenesis; indirect calorimetry; energy homeostasis

This article has been cited by other articles:

				R. Crescenzo, L. Lionetti, M. P. Mollica, M. Ferraro, E. D'Andrea, D. Mainieri, A. G. Dulloo, G. Liverini, and S. Iossa Altered skeletal muscle subsarcolemmal mitochondrial compartment during catch-up fat after caloric restriction. Diabetes, August 1, 2006; 55(8): 2286 - 2293. [Abstract] [Full Text] [PDF]

				J. J. Ramsey and K. Hagopian Energy Expenditure and Restriction of Energy Intake: Could Energy Restriction Alter Energy Expenditure in Companion Animals? J. Nutr., July 1, 2006; 136(7): 1958S - 1966S. [Abstract] [Full Text] [PDF]

				S. A. Evans, A. D. Parsons, and J. M. Overton Homeostatic responses to caloric restriction: influence of background metabolic rate J Appl Physiol, October 1, 2005; 99(4): 1336 - 1342. [Abstract] [Full Text] [PDF]

				W. A. Cupples Physiological regulation of food intake Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2005; 288(6): R1438 - R1443. [Full Text] [PDF]

				P. S. MacLean A peripheral perspective of weight regain Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2005; 288(6): R1447 - R1449. [Full Text] [PDF]