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Physiological Regulation of Appetite

The anorectic effect of fenfluramine is influenced by sex and stage of the estrous cycle in rats

Program in Neuroscience and Department of Psychology, Florida State University, Tallahassee, Florida

Submitted 16 November 2004 ; accepted in final form 5 January 2005

The controls of food intake differ in male and female rats. Daily food intake is typically greater in male rats, relative to female rats, and a decrease in food intake, coincident with the estrous stage of the ovarian reproductive cycle, is well documented in female rats. This estrous-related decrease in food intake has been attributed to a transient increase in the female rat's sensitivity to satiety signals generated during feeding bouts. Here, we investigated whether sex or stage of the estrous cycle modulate the satiety signal generated by fenfluramine, a potent serotonin (5-HT) releasing agent. To examine this hypothesis, food intake was monitored in male, diestrous female, and estrous female rats after intraperitoneal injections of 0, 0.25, and 1.0 mg/kg D-fenfluramine. The lower dose of fenfluramine decreased food intake only in diestrous and estrous females, suggesting that the minimally effective anorectic dose of fenfluramine is lower in female rats, relative to male rats. Although the larger dose of fenfluramine decreased food intake in both sexes, the duration of anorexia was greater in diestrous and estrous female rats, relative to male rats. Moreover, the magnitude of the anorectic effect of the larger dose of fenfluramine was greatest in estrous rats, intermediate in diestrous rats, and least in male rats. Thus our findings indicate that the anorectic effect of fenfluramine is modulated by gonadal hormone status.

serotonin; satiety; estradiol; food intake; meal size

This article has been cited by other articles:

				J. Santollo, M. D. Wiley, and L. A. Eckel Acute activation of ER{alpha} decreases food intake, meal size, and body weight in ovariectomized rats Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2007; 293(6): R2194 - R2201. [Abstract] [Full Text] [PDF]

				W. A. Cupples Physiological regulation of food intake Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2005; 288(6): R1438 - R1443. [Full Text] [PDF]