AJP - Regu Journal of Neurophysiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 288: R1525-R1535, 2005. First published January 13, 2005; doi:10.1152/ajpregu.00751.2004
0363-6119/05 $8.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
288/6/R1525    most recent
00751.2004v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (13)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cheon, Y.
Right arrow Articles by Nakamura, M. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cheon, Y.
Right arrow Articles by Nakamura, M. T.

CALL FOR PAPERS
Regulation of Lipid Metabolism and of Insulin Sensitivity by PPARs

Induction of overlapping genes by fasting and a peroxisome proliferator in pigs: evidence of functional PPAR{alpha} in nonproliferating species

Yewon Cheon,1 Takayuki Y. Nara,2 Mark R. Band,3 Jonathan E. Beever,4 Matthew A. Wallig,1,5 and Manabu T. Nakamura1,2

1Division of Nutritional Sciences, 2Department of Food Science and Human Nutrition, 3Biotechnology Center, 4Department of Animal Sciences, 5Department of Veterinary Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois

Submitted 4 November 2004 ; accepted in final form 10 January 2005

Peroxisome proliferator-activated receptor {alpha} (PPAR{alpha}), a key regulator of fatty acid oxidation, is essential for adaptation to fasting in rats and mice. However, physiological functions of PPAR{alpha} in other species, including humans, are controversial. A group of PPAR{alpha} ligands called peroxisome proliferators (PPs) causes peroxisome proliferation and hepatocarcinogenesis only in rats and mice. To elucidate the role of PPAR{alpha} in adaptation to fasting in nonproliferating species, we compared gene expressions in pig liver from fasted and clofibric acid (a PP)-fed groups against a control diet-fed group. As in rats and mice, fasting induced genes involved with mitochondrial fatty acid oxidation and ketogenesis in pigs. Those genes were also induced by clofibric acid feeding, indicating that PPAR{alpha} mediates the induction of these genes. In contrast to rats and mice, little or no induction of genes for peroxisomal or microsomal fatty acid oxidation was observed in clofibric acid-fed pigs. Histology showed no significant hyperplasia or hepatomegaly in the clofibric acid-fed pigs, whereas it showed a reduction of glycogen by clofibric acid, an effect of PPs also observed in rats. Copy number of PPAR{alpha} mRNA was higher in pigs than in mice and rats, suggesting that peroxisomal proliferation and hyperresponse of several genes to PPs seen only in rats and mice are unrelated to the abundance of PPAR{alpha}. In conclusion, PPAR{alpha} is likely to play a central role in adaptation to fasting in pig liver as in rats and mice.

clofibric acid; fatty acid oxidation; rats; mice; microarray


Address for reprint requests and other correspondence: M. T. Nakamura, Dept. of Food Science and Human Nutrition, Univ. of Illinois at Urbana-Champaign, 905 South Goodwin Ave., Bevier Hall #439, Urbana, IL (E-mail: mtnakamu{at}uiuc.edu)




This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. Luci, B. Giemsa, H. Kluge, and K. Eder
Clofibrate causes an upregulation of PPAR-{alpha} target genes but does not alter expression of SREBP target genes in liver and adipose tissue of pigs
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R70 - R77.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
R. Ringseis, A. Muschick, and K. Eder
Dietary Oxidized Fat Prevents Ethanol-Induced Triacylglycerol Accumulation and Increases Expression of PPAR{alpha} Target Genes in Rat Liver
J. Nutr., January 1, 2007; 137(1): 77 - 83.
[Abstract] [Full Text] [PDF]

Home page
 Drug Metab. Dispos.Home page
S. Luci, H. Kluge, F. Hirche, and K. Eder
Clofibrate Increases Hepatic Triiodothyronine (T3)- and Thyroxine (T4)-Glucuronosyltransferase Activities and Lowers Plasma T3 and T4 Concentrations in Pigs
Drug Metab. Dispos., November 1, 2006; 34(11): 1887 - 1892.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
J. I. Baum, D. K. Layman, G. G. Freund, K. A. Rahn, M. T. Nakamura, and B. E. Yudell
A Reduced Carbohydrate, Increased Protein Diet Stabilizes Glycemic Control and Minimizes Adipose Tissue Glucose Disposal in Rats
J. Nutr., July 1, 2006; 136(7): 1855 - 1861.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
Y. Li, T. Y. Nara, and M. T. Nakamura
Peroxisome proliferator-activated receptor {alpha} is required for feedback regulation of highly unsaturated fatty acid synthesis
J. Lipid Res., November 1, 2005; 46(11): 2432 - 2440.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. L. Peffer, X. Lin, and J. Odle
Hepatic {beta}-oxidation and carnitine palmitoyltransferase I in neonatal pigs after dietary treatments of clofibric acid, isoproterenol, and medium-chain triglycerides
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2005; 288(6): R1518 - R1524.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2005 by the American Physiological Society.