HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 288/6/R1689    most recent 00676.2004v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (10) Citing Articles via Google Scholar Google Scholar Articles by Watson, P. Articles by Maughan, R. J. Search for Related Content PubMed PubMed Citation Articles by Watson, P. Articles by Maughan, R. J.

NEUROHUMORAL CONTROL OF CARDIOVASCULAR FUNCTION

Blood-brain barrier integrity may be threatened by exercise in a warm environment

School of Sport and Exercise Sciences, Loughborough University, Leicestershire, United Kingdom

Submitted 1 October 2004 ; accepted in final form 12 January 2005

Seven active men were recruited to examine changes in the serum concentration of S100, a proposed peripheral marker of blood-brain barrier permeability, following prolonged exercise in temperate (T) and warm (W) conditions. Subjects were seated immersed to the neck in water at 35.0 (0.1)°C (T) or 39.0 (0.1)°C (W) for 30 min. Subjects then entered a room maintained at either 18.3 (1.8)°C (T) or 35.0 (0.3)°C (W) and completed 60 min of cycle exercise at 60% peak oxygen uptake. Serum S100 concentration was elevated after exercise in the W trial (+0.12 (0.10) µg/l; P = 0.02) but not after the T trial (P = 0.238). Water immersion and exercise elevated core temperature by 2.1 (0.5)°C to 39.5 (0.3)°C at the end of exercise in the W trial compared with a 0.9 (0.2)°C increase during the T trial (P < 0.001). Weighted mean skin temperature was higher throughout the W trial compared with the T trial (P < 0.001). Heart rate (P < 0.001) and blood glucose (P < 0.001) and lactate (P < 0.001) concentrations were elevated to a greater extent during exercise in the W trial than in the T trial. Ratings of perceived exertion (P < 0.001) and thermal comfort (P < 0.001) were markedly higher throughout the W trial than in the T trial. The results of this study demonstrate that serum S100 was elevated after water immersion and prolonged exercise in a warm environment, suggesting that blood-brain barrier permeability may be altered.

central fatigue; central nervous system; hyperthermia

This article has been cited by other articles:

				G. A. Selkirk, T. M. McLellan, H. E. Wright, and S. G. Rhind Mild endotoxemia, NF-{kappa}B translocation, and cytokine increase during exertional heat stress in trained and untrained individuals Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2008; 295(2): R611 - R623. [Abstract] [Full Text] [PDF]

				R.J. Maughan, S.M. Shirreffs, and P. Watson Exercise, Heat, Hydration and the Brain J. Am. Coll. Nutr., October 1, 2007; 26(suppl_5): 604S - 612S. [Abstract] [Full Text] [PDF]

				C. D. Bradford, J. D. Cotter, M. S. Thorburn, R. J. Walker, and D. F. Gerrard Exercise can be pyrogenic in humans Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R143 - R149. [Abstract] [Full Text] [PDF]