HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 288/6/R1800    most recent 00805.2004v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (7) Citing Articles via Google Scholar Google Scholar Articles by Kawaguchi, M. Articles by Bi, S. Search for Related Content PubMed PubMed Citation Articles by Kawaguchi, M. Articles by Bi, S.

APPETITE, OBESITY, DIGESTION, AND METABOLISM

Dorsomedial hypothalamic corticotropin-releasing factor mediation of exercise-induced anorexia

¹Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland; and ²Endocrine Disruptors and Dioxin Research Project, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba-Shi, Ibaraki, Japan

Submitted 30 November 2004 ; accepted in final form 20 January 2005

Running wheel access and resulting voluntary exercise alter food intake and reduce body weight. The neural mechanisms underlying these effects are unclear. In this study, we first assessed the effects of 7 days of running wheel access on food intake, body weight, and hypothalamic gene expression. We demonstrate that running wheel access significantly decreases food intake and body weight and results in a significant elevation of CRF mRNA expression in the dorsomedial hypothalamus (DMH) but not the paraventricular nucleus. Seven-day running wheel access also results in elevated arcuate nucleus and DMH neuropeptide Y gene expression. To assess a potential role for elevated DMH CRF activity in the activity-induced changes in food intake and body weight, we compared changes in food intake, body weight, and hypothalamic gene expression in rats receiving intracerebroventricular (ICV) CRF antagonist -helical CRF or vehicle with or without access to running wheels. During a 4-day period of running wheel access, we found that exercise-induced reductions of food intake and body weight were significantly attenuated by ICV injection of the CRF antagonist. The effect on food intake was specific to a blockade of activity-induced changes in meal size. Central CRF antagonist injection further increased DMH CRF mRNA expression in exercised rats. Together, these data suggest that DMH CRF play a critical role in the anorexia resulting from increased voluntary exercise.

neuropeptide Y; leptin; meal size; body weight; running wheel

This article has been cited by other articles:

				T. Ishikawa, W. Mizunoya, T. Shibakusa, K. Inoue, and T. Fushiki Transforming growth factor-beta in the brain regulates fat metabolism during endurance exercise Am J Physiol Endocrinol Metab, December 1, 2006; 291(6): E1151 - E1159. [Abstract] [Full Text] [PDF]

				A. J. Nelson, J. M. Juraska, T. I. Musch, and G. A. Iwamoto Neuroplastic adaptations to exercise: neuronal remodeling in cardiorespiratory and locomotor areas J Appl Physiol, December 1, 2005; 99(6): 2312 - 2322. [Abstract] [Full Text] [PDF]