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Am J Physiol Regul Integr Comp Physiol 289: R389-R394, 2005. First published March 31, 2005; doi:10.1152/ajpregu.00067.2005
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NEUROHUMORAL CONTROL OF CARDIOVASCULAR FUNCTION

Enhanced matrix metalloproteinase activity in skeletal muscles of rats with congestive heart failure

Hanne M. Schiøtz Thorud,1,2 Annicke Stranda,3 Jon-Arne Birkeland,1,2 Per K. Lunde,1,2 Ivar Sjaastad,1,2,4 Svein O. Kolset,3 Ole M. Sejersted,1,2 and Per O. Iversen3

1Institute for Experimental Medical Research and 4Department of Cardiology, Ullevaal University Hospital; and 2Center for Heart Failure Research and 3Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway

Submitted 1 February 2005 ; accepted in final form 25 March 2005

Patients with congestive heart failure (CHF) are prone to increased skeletal muscle fatigue. Elevated circulatory concentrations of tumor necrosis factor (TNF)-{alpha} and monocyte chemoattractant protein-1, which may stimulate matrix metalloproteinase (MMP) activity and, thereby, contribute to skeletal muscle dysfunction, are frequently found in CHF. However, whether skeletal muscle MMP activity is altered in CHF is unknown. Hence, we have used a gelatinase assay to assess the activity of MMP and tissue inhibitors of MMP in single skeletal muscles of rats with CHF 6 wk after induction of myocardial infarction. Sham-operated (Sham) rats were used as controls. We also measured the gene expression and protein contents of MMP-2 and MMP-9 in skeletal muscles of these rats. Plasma MMP activity was nearly seven times higher (P < 0.05) in CHF than in Sham rats. Concomitantly, the MMP activity within single slow- and fast-twitch skeletal muscles of CHF rats increased two- to fourfold compared with Sham animals, whereas tissue inhibitor of MMP activity did not differ (P > 0.05). Preformed MMP-2 and MMP-9 were probably activated in CHF, because neither their gene expression nor protein levels were altered (P > 0.05). Serum concentrations of TNF-{alpha} and monocyte chemoattractant protein-1 remained unchanged (P > 0.05) between CHF and Sham rats during the 6-wk observation period. We conclude that development of CHF in rats enhances MMP activity, which in turn may distort the normal contractile function of skeletal muscle, thereby contributing to increased skeletal muscle fatigue.

cytokines; fatigue; myocardial infarction


Address for reprint requests and other correspondence: P. O. Iversen, Dept. of Nutrition, POB 1046 Blindern, 0316 Oslo, Norway (E-mail: poiversen{at}hotmail.com)




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