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Am J Physiol Regul Integr Comp Physiol 289: R486-R494, 2005; doi:10.1152/ajpregu.00846.2004
0363-6119/05 $8.00
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APPETITE, OBESITY, DIGESTION, AND METABOLISM

Dietary fish oil positively regulates plasma leptin and adiponectin levels in sucrose-fed, insulin-resistant rats

Andrea S. Rossi,1 Yolanda B. Lombardo,1 Jean-Marc Lacorte,2 Adriana G. Chicco,1 Christine Rouault,3,4 Gérard Slama,4 and Salwa W. Rizkalla3,4

1Department of Biochemistry, School of Biochemistry, University of Litoral, Santa Fe, Argentina; and 2Institut National de la Santé et de la Recherche Médicale (INSERM) U 505 and 3INSERM U 341, 4Department of Diabetes, Hotel Dieu, Hospital, Paris, France

Submitted 16 December 2004 ; accepted in final form 4 April 2005

Insulin resistance and adiposity induced by a long-term sucrose-rich diet (SRD) in rats could be reversed by fish oil (FO). Regulation of plasma leptin and adiponectin levels, as well as their gene expression, by FO might be implicated in these findings. This study was designed to evaluate the long-term regulation of leptin and adiponectin by dietary FO in a dietary model of insulin resistance induced by long-term SRD in rats and to determine their impact on adiposity and insulin sensitivity. Rats were randomized to consume a control diet (CD; n = 25) or an SRD (n = 50) for 7 mo. Subsequently, the SRD-fed rats were randomized to consume SRD+FO or to continue on SRD for an additional 2 mo. Long-term SRD induced overweight and decreased both plasma leptin and adiponectin levels without change in gene expression. Dyslipidemia, adiposity, and insulin resistance accompanied these modifications. Shifting the source of fat to FO for 2 mo increased plasma levels of both adipokines, reversed insulin resistance and dyslipidemia, and improved adiposity. These results were not associated with modifications in gene expression. These results suggest that increasing both adipokines by dietary FO might play an essential role in the normalization of insulin resistance and adiposity in dietary-induced, insulin-resistant models.

adipokines; insulin resistance; sucrose-rich diet


Address for reprint requests and other correspondence: Y. B. Lombardo, Dept. of Biochemistry, School of Biochemistry, Univ. of Litoral, Ciudad Universitaria, Paraje "El Pozo" C.C 242 (3000) Santa Fe, Argentina(E-mail: ylombard{at}fbcb.unl.edu.ar)




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