HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 289/4/R1090    most recent 00290.2005v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (9) Citing Articles via Google Scholar Google Scholar Articles by Little, T. J. Articles by Feinle-Bisset, C. Search for Related Content PubMed PubMed Citation Articles by Little, T. J. Articles by Feinle-Bisset, C.

APPETITE, OBESITY, DIGESTION, AND METABOLISM

Dose-related effects of lauric acid on antropyloroduodenal motility, gastrointestinal hormone release, appetite, and energy intake in healthy men

¹Department of Medicine, University of Adelaide, Royal Adelaide Hospital, Adelaide, South Australia, Australia; ²Department of Gastroenterology, University Hospital, Utrecht, The Netherlands; and ³School of Pharmacy, University of Otago, Dunedin, New Zealand

Submitted 26 April 2005 ; accepted in final form 12 June 2005

We recently reported that intraduodenal infusion of lauric acid (C12) (0.375 kcal/min, 106 mM) stimulates isolated pyloric pressure waves (IPPWs), inhibits antral and duodenal pressure waves (PWs), stimulates release of cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1), and suppresses energy intake and that these effects are much greater than those seen in response to isocaloric decanoic acid (C10) infusion. Administration of C12 was, however, associated with nausea, confounding interpretation of the results. The aim of this study was to evaluate the effects of different intraduodenal doses of C12 on antropyloroduodenal (APD) motility, plasma CCK and GLP-1 concentrations, appetite, and energy intake. Thirteen healthy males were studied on 4 days in double-blind, randomized fashion. APD pressures, plasma CCK and GLP-1 concentrations, and appetite perceptions were measured during 90-min ID infusion of C12 at 0.1 (14 mM), 0.2 (28 mM), or 0.4 (56 mM) kcal/min or saline (control; rate 4 ml/min). Energy intake was determined at a buffet meal immediately following infusion. C12 dose-dependently stimulated IPPWs, decreased antral and duodenal motility, and stimulated secretion of CCK and GLP-1 (r > 0.4, P < 0.05 for all). C12 (0.4 kcal/min) suppressed energy intake compared with control, C12 (0.1 kcal/min), and C12 (0.2 kcal/min) (P < 0.05). These effects were observed in the absence of nausea. In conclusion, intraduodenal C12 dose-dependently modulated APD motility and gastrointestinal hormone release in healthy male subjects, whereas effects on energy intake were only apparent with the highest dose infused (0.4 kcal/min), possibly because only at this dose was modulation of APD motility and gastrointestinal hormone secretion sufficient for a suppressant effect on energy intake.

free fatty acid; cholecystokinin; glucagon-like peptide-1; pyloric motility

This article has been cited by other articles:

				R. V Seimon, T. Wooster, B. Otto, M. Golding, L. Day, T. J Little, M. Horowitz, P. M Clifton, and C. Feinle-Bisset The droplet size of intraduodenal fat emulsions influences antropyloroduodenal motility, hormone release, and appetite in healthy males Am. J. Clinical Nutrition, June 1, 2009; 89(6): 1729 - 1736. [Abstract] [Full Text] [PDF]

				M. Foltz, J. Maljaars, E. A. H. Schuring, R. J. P. van der Wal, T. Boer, G. S. M. Duchateau, H. P. F. Peters, F. Stellaard, and A. A. Masclee Intragastric layering of lipids delays lipid absorption and increases plasma CCK but has minor effects on gastric emptying and appetite Am J Physiol Gastrointest Liver Physiol, May 1, 2009; 296(5): G982 - G991. [Abstract] [Full Text] [PDF]

				K. L Feltrin, T. J Little, J. H Meyer, M. Horowitz, T. Rades, J. Wishart, and C. Feinle-Bisset Comparative effects of intraduodenal infusions of lauric and oleic acids on antropyloroduodenal motility, plasma cholecystokinin and peptide YY, appetite, and energy intake in healthy men Am. J. Clinical Nutrition, May 1, 2008; 87(5): 1181 - 1187. [Abstract] [Full Text] [PDF]

				A. N. Pilichiewicz, P. Papadopoulos, I. M. Brennan, T. J. Little, J. H. Meyer, J. M. Wishart, M. Horowitz, and C. Feinle-Bisset Load-dependent effects of duodenal lipid on antropyloroduodenal motility, plasma CCK and PYY, and energy intake in healthy men Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2007; 293(6): R2170 - R2178. [Abstract] [Full Text] [PDF]

				K. L. Feltrin, T. J. Little, J. H. Meyer, M. Horowitz, T. Rades, J. Wishart, and C. Feinle-Bisset Effects of lauric acid on upper gut motility, plasma cholecystokinin and peptide YY, and energy intake are load, but not concentration, dependent in humans J. Physiol., June 1, 2007; 581(2): 767 - 777. [Abstract] [Full Text] [PDF]

				A. N. Pilichiewicz, T. J. Little, I. M. Brennan, J. H. Meyer, J. M. Wishart, B. Otto, M. Horowitz, and C. Feinle-Bisset Effects of load, and duration, of duodenal lipid on antropyloroduodenal motility, plasma CCK and PYY, and energy intake in healthy men Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2006; 290(3): R668 - R677. [Abstract] [Full Text] [PDF]