| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
INVITED REVIEW
ERNEST H. STARLING DISTINGUISHED LECTURESHIP OF THE WATER AND ELECTROLYTE HOMEOSTASIS SECTION, 2004
Division of Nephrology and Hypertension, and Cardiovascular-Kidney Institute, Georgetown University, Washington, DC
There is growing evidence that oxidative stress contributes to hypertension. Oxidative stress can precede the development of hypertension. In almost all models of hypertension, there is oxidative stress that, if corrected, lowers BP, whereas creation of oxidative stress in normal animals can cause hypertension. There is overexpression of the p22phox and Nox-1 components of NADPH oxidase and reduced expression of extracellular superoxide dismutase (EC-SOD) in the kidneys of ANG II-infused rodents, whereas there is overexpression of p47phox and gp91phox and reduced expression of intracellular SOD with salt loading. Several mechanisms have been identified that can make oxidative stress self-sustaining. Reactive oxygen species (ROS) can enhance afferent arteriolar tone and reactivity both indirectly via potentiation of tubuloglomerular feedback and directly by microvascular mechanisms that diminish endothelium-derived relaxation factor/nitric oxide responses, generate a cyclooxygenase-2-dependent endothelial-derived contracting factor that activates thromboxane-prostanoid receptors, and enhance vascular smooth muscle cells reactivity. ROS can diminish the efficiency with which the kidney uses O2 for Na+ transport and thereby diminish the PO2 within the kidney cortex. This may place a break on further ROS generation yet could further enhance vasculopathy and hypertension. There is a tight relationship between oxidative stress in the kidney and the development and maintenance of hypertension.
reactive oxygen species; superoxide anion; nitric oxide synthase; thromboxane-prostanoid receptors; salt sensitivity
This article has been cited by other articles:
|
|
 |
|
  M. P. Koeners, B. Braam, D. M. van der Giezen, R. Goldschmeding, and J. A. Joles A perinatal nitric oxide donor increases renal vascular resistance and ameliorates hypertension and glomerular injury in adult fawn-hooded hypertensive rats Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2008; 294(6): R1847 - R1855. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Carlstrom, E. Y. Lai, A. Steege, M. Sendeski, Z. Ma, S. Zabihi, U. J. Eriksson, A. Patzak, and A. E. G. Persson Nitric Oxide Deficiency and Increased Adenosine Response of Afferent Arterioles in Hydronephrotic Mice With Hypertension Hypertension, May 1, 2008; 51(5): 1386 - 1392. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. BAUMANN, C. STEHOUWER, J. SCHEIJEN, U. HEEMANN, H. STRUIJKER BOUDIER, and C. SCHALKWIJK N{varepsilon}-(Carboxymethyl)lysine during the Early Development of Hypertension Ann. N.Y. Acad. Sci., April 1, 2008; 1126(1): 201 - 204. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Palm, S. G. Connors, M. Mendonca, W. J. Welch, and C. S. Wilcox Angiotensin II Type 2 Receptors and Nitric Oxide Sustain Oxygenation in the Clipped Kidney of Early Goldblatt Hypertensive Rats Hypertension, February 1, 2008; 51(2): 345 - 351. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Han, H. Li, V. A. M. Villar, A. M. Pascua, M. I. Dajani, X. Wang, A. Natarajan, M. T. Quinn, R. A. Felder, P. A. Jose, et al. Lipid Rafts Keep NADPH Oxidase in the Inactive State in Human Renal Proximal Tubule Cells Hypertension, February 1, 2008; 51(2): 481 - 487. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. I. Schrader, D. A. Kinzenbaw, A. W. Johnson, F. M. Faraci, and S. P. Didion IL-6 Deficiency Protects Against Angiotensin II Induced Endothelial Dysfunction and Hypertrophy Arterioscler. Thromb. Vasc. Biol., December 1, 2007; 27(12): 2576 - 2581. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Chen, K. Patel, S. G. Connors, M. Mendonca, W. J. Welch, and C. S. Wilcox Acute antihypertensive action of Tempol in the spontaneously hypertensive rat Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3246 - H3253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Palm, M. L. Onozato, Z. Luo, and C. S. Wilcox Dimethylarginine dimethylaminohydrolase (DDAH): expression, regulation, and function in the cardiovascular and renal systems Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3227 - H3245. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Soodvilai, Z. Jia, and T. Yang Hydrogen peroxide stimulates chloride secretion in primary inner medullary collecting duct cells via mPGES-1-derived PGE2 Am J Physiol Renal Physiol, November 1, 2007; 293(5): F1571 - F1576. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Guzik, N. E. Hoch, K. A. Brown, L. A. McCann, A. Rahman, S. Dikalov, J. Goronzy, C. Weyand, and D. G. Harrison Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction J. Exp. Med., October 1, 2007; 204(10): 2449 - 2460. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Silva and P. Soares-da-Silva Reactive oxygen species and the regulation of renal Na+-K+-ATPase in opossum kidney cells Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2007; 293(4): R1764 - R1770. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Datla, G. J. Dusting, T. A. Mori, C. J. Taylor, K. D. Croft, and F. Jiang Induction of Heme Oxygenase-1 In Vivo Suppresses NADPH Oxidase Derived Oxidative Stress Hypertension, October 1, 2007; 50(4): 636 - 642. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. W. Chapleau The Continuing Saga of Neuronal Oxidative Stress in Hypertension: Nox, Nox Who's There, and Where? Hypertension, October 1, 2007; 50(4): 600 - 602. [Full Text] [PDF]
|
|
|
|
 |
|
 D. Wang, P. S. Gill, T. Chabrashvili, M. L. Onozato, J. Raggio, M. Mendonca, K. Dennehy, M. Li, P. Modlinger, J. Leiper, et al. Isoform-Specific Regulation by NG,NG-Dimethylarginine Dimethylaminohydrolase of Rat Serum Asymmetric Dimethylarginine and Vascular Endothelium-Derived Relaxing Factor/NO Circ. Res., September 14, 2007; 101(6): 627 - 635. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Sachse and G. Wolf Angiotensin II Induced Reactive Oxygen Species and the Kidney J. Am. Soc. Nephrol., September 1, 2007; 18(9): 2439 - 2446. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fujita, K. Ando, A. Nagae, and T. Fujita Sympathoexcitation by Oxidative Stress in the Brain Mediates Arterial Pressure Elevation in Salt-Sensitive Hypertension Hypertension, August 1, 2007; 50(2): 360 - 367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Wang, I. Armando, L. D. Asico, C. Escano, X. Wang, Q. Lu, R. A. Felder, C. G. Schnackenberg, D. R. Sibley, G. M. Eisner, et al. The elevated blood pressure of human GRK4{gamma} A142V transgenic mice is not associated with increased ROS production Am J Physiol Heart Circ Physiol, May 1, 2007; 292(5): H2083 - H2092. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Nouri, P. Gill, M. Li, C. S. Wilcox, and W. J. Welch p22phox in the macula densa regulates single nephron GFR during angiotensin II infusion in rats Am J Physiol Heart Circ Physiol, April 1, 2007; 292(4): H1685 - H1689. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Cambonie, B. Comte, C. Yzydorczyk, T. Ntimbane, N. Germain, N. L. O. Le, P. Pladys, C. Gauthier, I. Lahaie, D. Abran, et al. Antenatal antioxidant prevents adult hypertension, vascular dysfunction, and microvascular rarefaction associated with in utero exposure to a low-protein diet Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2007; 292(3): R1236 - R1245. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Wesseling, J. A. Joles, H. van Goor, H. A. Bluyssen, P. Kemmeren, F. C. Holstege, H. A. Koomans, and B. Braam Transcriptome-based identification of pro- and antioxidative gene expression in kidney cortex of nitric oxide-depleted rats Physiol Genomics, January 17, 2007; 28(2): 158 - 167. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Rodriguez-Iturbe, L. Sepassi, Y. Quiroz, Z. Ni, and N. D. Vaziri Association of mitochondrial SOD deficiency with salt-sensitive hypertension and accelerated renal senescence J Appl Physiol, January 1, 2007; 102(1): 255 - 260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. V. Shah, R. Baliga, M. Rajapurkar, and V. A. Fonseca Oxidants in Chronic Kidney Disease J. Am. Soc. Nephrol., January 1, 2007; 18(1): 16 - 28. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Just, A. J. M. Olson, C. L. Whitten, and W. J. Arendshorst Superoxide mediates acute renal vasoconstriction produced by angiotensin II and catecholamines by a mechanism independent of nitric oxide Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H83 - H92. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Wang, P. Jose, and C. S. Wilcox beta1 Receptors Protect the Renal Afferent Arteriole of Angiotensin-Infused Rabbits from Norepinephrine-Induced Oxidative Stress J. Am. Soc. Nephrol., December 1, 2006; 17(12): 3347 - 3354. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Herrera, A. Ferrebuz, E. G. MacGregor, and B. Rodriguez-Iturbe Mycophenolate Mofetil Treatment Improves Hypertension in Patients with Psoriasis and Rheumatoid Arthritis J. Am. Soc. Nephrol., December 1, 2006; 17(12_suppl_3): S218 - S225. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. J. Welch, T. Chabrashvili, G. Solis, Y. Chen, P. S. Gill, S. Aslam, X. Wang, H. Ji, K. Sandberg, P. Jose, et al. Role of Extracellular Superoxide Dismutase in the Mouse Angiotensin Slow Pressor Response Hypertension, November 1, 2006; 48(5): 934 - 941. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Schluter, R. Grimm, A. Steinbach, G. Lorenz, R. Rettig, and O. Grisk Neonatal sympathectomy reduces NADPH oxidase activity and vascular resistance in spontaneously hypertensive rat kidneys Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2006; 291(2): R391 - R399. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. E. Taylor, P. Glocka, M. Liang, and A. W. Cowley Jr NADPH Oxidase in the Renal Medulla Causes Oxidative Stress and Contributes to Salt-Sensitive Hypertension in Dahl S Rats Hypertension, April 1, 2006; 47(4): 692 - 698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Kopkan and D. S.A. Majid Enhanced Superoxide Activity Modulates Renal Function in NO-Deficient Hypertensive Rats Hypertension, March 1, 2006; 47(3): 568 - 572. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Wilcox Special feature: cardiovascular-kidney interactions in health and disease Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2006; 290(1): R34 - R36. [Full Text] [PDF]
|
|
|
|
|
|
K. Patel, Y. Chen, K. Dennehy, J. Blau, S. Connors, M. Mendonca, M. Tarpey, M. Krishna, J. B. Mitchell, W. J. Welch, et al. Acute antihypertensive action of nitroxides in the spontaneously hypertensive rat Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2006; 290(1): R37 - R43. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
