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This Article Full Text Full Text (PDF) All Versions of this Article: 291/2/R473    most recent 00919.2005v2 00919.2005v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (7) Citing Articles via Google Scholar Google Scholar Articles by Szentirmai, E. Articles by Krueger, J. M. Search for Related Content PubMed PubMed Citation Articles by Szentirmai, E. Articles by Krueger, J. M.

SLEEP AND TEMPERATURE REGULATION

Central administration of neuropeptide Y induces wakefulness in rats

¹Department of Physiology, A. Szent-Györgyi Medical and Pharmaceutical Center, University of Szeged, Szeged, Hungary; and ²Neuroscience Program, Washington State University, Pullman, Washington

Submitted 30 December 2005 ; accepted in final form 9 February 2006

Neuropeptide Y (NPY) is a well-characterized neuromodulator in the central nervous system, primarily implicated in the regulation of feeding. NPY, orexins, and ghrelin form a hypothalamic food intake regulatory circuit. Orexin and ghrelin are also implicated in sleep-wake regulation. In the present experiments, we studied the sleep-modulating effects of central administration of NPY in rats. Rats received intracerebroventricular injection of physiological saline or three different doses of NPY (0.4, 2, and 10 µg in a volume of 4 µl) at light onset. Another group of rats received bilateral microinjection of saline or 2 µg NPY in the lateral hypothalamus in a volume of 0.2 µl. Sleep-wake activity and motor activity were recorded for 23 h. Food intake after the control and treatment injections was also measured on separate days. Intracerebroventricular and lateral hypothalamic administration of NPY suppressed non-rapid-eye-movement sleep and rapid-eye-movement sleep in rats during the first hour after the injection and also induced changes in electroencephalogram delta power spectra. NPY stimulated food intake in the first hour after both routes of administration. Data are consistent with the hypothesis that NPY has a role in the integration of feeding, metabolism, and sleep regulation.

food intake; lateral hypothalamus; electroencephalogram; fast-Fourier transformation; slow-wave activity

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