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Am J Physiol Regul Integr Comp Physiol 291: R1111-R1119, 2006. First published April 20, 2006; doi:10.1152/ajpregu.00896.2005
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ENVIRONMENTAL, EXERCISE AND RESPIRATORY PHYSIOLOGY

Long-term facilitation of ventilation and genioglossus muscle activity is evident in the presence of elevated levels of carbon dioxide in awake humans

Daniel P. Harris,1,2 Arvind Balasubramaniam,1 M. Safwan Badr,1,3,4 and Jason H. Mateika1,2,3

1John D. Dingell Veterans Administration Medical Center, Detroit, Michigan; and Departments of 2Physiology, 3Internal Medicine, and 4Biomedical Engineering, Wayne State University School of Medicine, Detroit, Michigan

Submitted 20 December 2005 ; accepted in final form 17 April 2006

We hypothesized that long-term facilitation (LTF) of minute ventilation and peak genioglossus muscle activity manifests itself in awake healthy humans when carbon dioxide is sustained at elevated levels. Eleven subjects completed two trials. During trial 1, baseline carbon dioxide levels were maintained during and after exposure to eight 4-min episodes of hypoxia. During trial 2, carbon dioxide was sustained 5 mmHg above baseline levels during exposure to episodic hypoxia. Seven subjects were exposed to sustained elevated levels of carbon dioxide in the absence of episodic hypoxia, which served as a control experiment. Minute ventilation was measured during trial 1, trial 2, and the control experiment. Peak genioglossus muscle activity was measured during trial 2. Minute ventilation during the recovery period of trial 1 was similar to baseline (9.3 ± 0.5 vs. 9.2 ± 0.7 l/min). Likewise, minute ventilation remained unchanged during the control experiment (beginning vs. end of control experiment, 14.4 ± 1.7 vs. 14.7 ± 1.4 l/min). In contrast, minute ventilation and peak genioglossus muscle activity during the recovery period of trial 2 was greater than baseline (minute ventilation: 28.4 ± 1.7 vs. 19.6 ± 1.0 l/min, P < 0.001; peak genioglossus activity: 1.6 ± 0.3 vs. 1.0 fraction of baseline, P < 0.001). We conclude that exposure to episodic hypoxia is necessary to induce LTF of minute ventilation and peak genioglossus muscle activity and that LTF is only evident in awake humans in the presence of sustained elevated levels of carbon dioxide.

genioglossus muscle; episodic hypoxia


Address for reprint requests and other correspondence: J. H. Mateika, John D. Dingell VA Medical Center, 4646 John R (11R), Rm. 4308, Detroit, MI, 48201 (e-mail: jmateika{at}med.wayne.edu)




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