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Am J Physiol Regul Integr Comp Physiol 291: R1527-R1532, 2006. First published June 29, 2006; doi:10.1152/ajpregu.00186.2006
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SLEEP AND TEMPERATURE REGULATION

Effects of sleep deprivation on the development of autoimmune disease in an experimental model of systemic lupus erythematosus

Beatriz Duarte Palma,1 Alexandre Gabriel, Jr.,2 Fernando A. B. Colugnati,1 and Sergio Tufik1

1Department of Psychobiology and 2Laboratory of Medical Investigation, Universidade Federal de São Paulo, São Paulo, Brazil

Submitted 17 March 2006 ; accepted in final form 23 June 2006

Sleep is hypothesized to play a restorative role on immune system. In addition, disturbed sleep is thought to impair host defense mechanisms. Chronic sleep deprivation is a common occurrence in modern society and has been observed in a number of chronic inflammatory conditions, such as systemic lupus erythematosus (SLE). New Zealand Black/New Zealand White (NZB/NZW) F1 mice develop an autoimmune disease that strongly resembles SLE in humans, exhibiting high titers of antinuclear antibodies associated with the development of rapidly progressive and lethal glomerulonephritis. On the basis of this evidence, the present study examined the onset and progress of lupus in as-yet healthy female mice submitted to sleep deprivation. Sleep deprivation was accomplished by two 96-h periods in the multiple-platform method when mice were 10 wk old, and they were observed until 28 wk of age. Blood samples were collected from the orbital plexus fortnightly to evaluate serum antinuclear antibodies and anti-double-stranded DNA. Proteinuria and longevity as well as body weight were also assessed. The results indicated that mice submitted to sleep deprivation exhibited an earlier onset of the disease, as reflected by the increased number of antinuclear antibodies. However, no statistical difference was found in the other parameters analyzed. According to these results, sleep deprivation could be considered as a risk factor for the onset but not for the evolution of the disease.

sleep; New Zealand Black/New Zealand White F1 mice; antinuclear antibody


Address for reprint requests and other correspondence: B. D. Palma, Departamento de Psicobiologia, Universidade Federal de São Paulo, Rua Botucatu, 862-1° andar, 04023-062 Vila Clementino, São Paulo, Brazil (e-mail: biapalma{at}uol.com.br)




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A. Zager, M. L. Andersen, F. S. Ruiz, I. B. Antunes, and S. Tufik
Effects of acute and chronic sleep loss on immune modulation of rats
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R504 - R509.
[Abstract] [Full Text] [PDF]


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