HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 292/1/R652    most recent 00055.2006v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (4) Citing Articles via Google Scholar Google Scholar Articles by Stricker, E. M. Articles by Smith, J. C. Search for Related Content PubMed PubMed Citation Articles by Stricker, E. M. Articles by Smith, J. C.

WATER AND ELECTROLYTE HOMEOSTASIS

Inhibition of NaCl appetite when DOCA-treated rats drink saline

¹Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of ²Psychology and ³Biological Sciences, Florida State University, Tallahassee, Florida

Submitted 20 January 2006 ; accepted in final form 14 September 2006

Marked increases in the consumption of concentrated NaCl solution were elicited in rats by daily injection of the synthetic mineralocorticoid, deoxycorticosterone acetate (DOCA). DOCA-treated rats drank different volumes of NaCl solution depending on its concentration (between 0.15 M and 0.50 M), with less consumed (in milliliters) the more concentrated the fluid was. In consequence, total Na⁺ intake (in milliequivalents) was roughly similar in all groups. Gastric emptying of Na⁺ also diminished as the concentration of the ingested NaCl solution increased, and the delivery of Na⁺ to the small intestine was remarkably similar in all groups. Cumulative volume of ingested fluid in the stomach and small intestine was very closely related to intake (in milliliters) of the concentrated NaCl solutions. Systemic plasma Na⁺ levels did not increase until after rats stopped consuming concentrated NaCl solution, although they were elevated at the onset of water ingestion. The situation appeared to be different when 0.15 M NaCl was consumed. This isotonic solution emptied and was absorbed relatively rapidly, and DOCA-treated rats drank larger amounts of it throughout a 1-h test period than when they drank concentrated NaCl solutions. Collectively, these findings suggest that saline consumption by DOCA-treated rats may be inhibited by two presystemic factors, one related to the volume of ingested fluid (i.e., distension of the stomach and small intestine) and one related to its concentration (i.e., elevated osmolality of fluid in the small intestine and/or in adjacent visceral tissue).

gastric emptying; mineralocorticoids; osmoregulation; thirst

This article has been cited by other articles:

				A. Godino, L. A. De Luca Jr., J. Antunes-Rodrigues, and L. Vivas Oxytocinergic and serotonergic systems involvement in sodium intake regulation: satiety or hypertonicity markers? Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1027 - R1036. [Abstract] [Full Text] [PDF]

				C. A. Smith, K. S. Curtis, J. C. Smith, and E. M. Stricker Presystemic influences on thirst, salt appetite, and vasopressin secretion in the hypovolemic rat Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2007; 292(5): R2089 - R2099. [Abstract] [Full Text] [PDF]