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Am J Physiol Regul Integr Comp Physiol 292: R1315-R1319, 2007. First published November 16, 2006; doi:10.1152/ajpregu.00396.2006
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SLEEP AND TEMPERATURE REGULATION

Differential response of type 2 deiodinase gene expression to photoperiod between photoperiodic Fischer 344 and nonphotoperiodic Wistar rats

¹Division of Biomodeling, Graduate School of Bioagricultural Sciences and ³Institute for Advanced Research, Nagoya University, Chikusa-ku, Nagoya; and ²Department of Applied Biological Chemistry, Faculty of Agriculture, Utsunomiya University, Mine-machi, Utsunomiya, Tochigi, Japan

Submitted 7 June 2006 ; accepted in final form 14 November 2006

The molecular basis of seasonal or nonseasonal breeding remains unknown. Although laboratory rats are generally regarded as photoperiod-insensitive species, the testicular weight of the Fischer 344 (F344) strain responds to photoperiod. Recently, it was clarified that photoperiodic regulation of type 2 iodothyronine deiodinase (Dio2) in the mediobasal hypothalamus (MBH) is critical in photoperiodic gonadal regulation. Strain-dependent differences in photoperiod sensitivity may now provide the opportunity to address the regulatory mechanism of seasonality by studying Dio2 expression. Therefore, in the present study, we examined the effect of photoperiod on Dio2 expression in photoperiod-sensitive F344 and photoperiod-insensitive Wistar rats. A statistically significant difference was observed between short and long days in terms of testicular weight and Dio2 expression in the F344 strain, while no difference was observed in the Wistar strain. These results suggest that differential responses of the Dio2 gene to photoperiod may determine the strain-dependent differences in photoperiod sensitivity in laboratory rats.

mediobasal hypothalamus; testicular weight; photoperiodism

This article has been cited by other articles:

				S. Yasuo and T. Yoshimura Comparative analysis of the molecular basis of photoperiodic signal transduction in vertebrates Integr. Comp. Biol., November 1, 2009; 49(5): 507 - 518. [Abstract] [Full Text] [PDF]

				M. J Paul, I. Zucker, and W. J Schwartz Tracking the seasons: the internal calendars of vertebrates Phil Trans R Soc B, January 27, 2008; 363(1490): 341 - 361. [Abstract] [Full Text] [PDF]