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Am J Physiol Regul Integr Comp Physiol 292: R1594-R1602, 2007. First published December 28, 2006; doi:10.1152/ajpregu.00251.2006
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ENVIRONMENTAL, EXERCISE AND RESPIRATORY PHYSIOLOGY

Effect of two different intense training regimens on skeletal muscle ion transport proteins and fatigue development

Magni Mohr,1 Peter Krustrup,1 Jens Jung Nielsen,1 Lars Nybo,1 Martin Krøyer Rasmussen,2 Carsten Juel,2 and Jens Bangsbo1

Copenhagen Muscle Research Centre, 1Institute of Exercise and Sport Sciences, Department of Human Physiology and 2Department of Molecular Biology, University of Copenhagen, Copenhagen, Denmark

Submitted 11 April 2006 ; accepted in final form 22 December 2006

This study examined the effect of two different intense exercise training regimens on skeletal muscle ion transport systems, performance, and metabolic response to exercise. Thirteen subjects performed either sprint training [ST; 6-s sprints (n = 6)], or speed endurance training [SET; 30-s runs ~130% VO2 max, n = 7]. Training in the SET group provoked higher (P < 0.05) plasma K+ levels and muscle lactate/H+ accumulation. Only in the SET group was the amount of the Na+/H+ exchanger isoform 1 (31%) and Na+-K+-ATPase isoform {alpha}2 (68%) elevated (P < 0.05) after training. Both groups had higher (P < 0.05) levels of Na+-K+-ATPase beta1-isoform and monocarboxylate transporter 1 (MCT1), but no change in MCT4 and Na+-K+-ATPase {alpha}1-isoform. Both groups had greater (P < 0.05) accumulation of lactate during exhaustive exercise and higher (P < 0.05) rates of muscle lactate decrease after exercise. The ST group improved (P < 0.05) sprint performance, whereas the SET group elevated (P < 0.05) performance during exhaustive continuous treadmill running. Improvement in the Yo-Yo intermittent recovery test was larger (P < 0.05) in the SET than ST group (29% vs. 10%). Only the SET group had a decrease (P < 0.05) in fatigue index during a repeated sprint test. In conclusion, turnover of lactate/H+ and K+ in muscle during exercise does affect the adaptations of some but not all related muscle ion transport proteins with training. Adaptations with training do have an effect on the metabolic response to exercise and specific improvement in work capacity.

muscle metabolites; Na+/K+ pump; intermittent exercise performance; monocarboxylate transporter; Na+/H+ exchanger


Address for reprint requests and other correspondence: J. Bangsbo, Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, Universitetsparken 13, DK-2100 Copenhagen Ø, Denmark (e-mail: jbangsbo{at}aki.ku.dk)




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