HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 292/5/R1819    most recent 00339.2006v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (1) Citing Articles via Google Scholar Google Scholar Articles by De Jonghe, B. C. Articles by Covasa, M. Search for Related Content PubMed PubMed Citation Articles by De Jonghe, B. C. Articles by Covasa, M.

APPETITE, OBESITY, DIGESTION, AND METABOLISM

Conditioned preference for sweet stimuli in OLETF rat: effects of food deprivation

¹Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania; and ²Department of Neural and Behavioral Sciences, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania

Submitted 19 May 2006 ; accepted in final form 30 January 2007

The Otsuka Long-Evans Tokushima Fatty (OLETF) rat, an outbred strain of Long- Evans Tokushima Otsuka rat (LETO) that lacks CCK-1 receptor expression, is hyperphagic and develops obesity and type-2 diabetes. The present study sought to assess how OLETF rats alter intake, preference, and conditioned preference of palatable solutions after acute food deprivation. Our results show that after 24 h chow restriction, LETO rats increase both sucrose intake and two-bottle sucrose preference relative to their free-fed baseline, whereas OLETF rats do not increase sucrose intake (0.3 M or 1.0 M sucrose) or preference (1.0 M vs. 0.3 M sucrose) when they are food deprived. In contrast, OLETF rats exhibit a higher conditioned flavor preference when sucrose is used as unconditioned stimulus (US) relative to LETO rats, whether overnight food restricted (81% vs. 71% for OLETF and LETO rats, respectively) or free fed (82% vs. 54% for OLETF and LETO rats, respectively) during the test. When a noncaloric saccharin solution is used as US, OLETF rats show a higher preference for the saccharin-associated flavor relative to LETO rats when nondeprived (76% vs. 58% for OLETF and LETO rats, respectively); however, neither strain shows differential conditioned flavor preference for saccharin in the deprivation state during the test. These findings suggest that OLETF rats fail to integrate postabsorptive and orosensory effects of sucrose in a conditioning setting to influence intake. Thus, it appears that OLETF rats form preferences for sucrose based largely on orosensory and hedonic properties of the solution, rather than caloric value.

food intake; CCK-1 receptor; hyperphagia; diet-induced obesity; palatability

This article has been cited by other articles:

				A. Hajnal, N. K. Acharya, P. S. Grigson, M. Covasa, and R. C. Twining Obese OLETF rats exhibit increased operant performance for palatable sucrose solutions and differential sensitivity to D2 receptor antagonism Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2007; 293(5): R1846 - R1854. [Abstract] [Full Text] [PDF]