AJP - Regu Add DOIs to your references at manuscript stage!
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 293: R78-R82, 2007. First published March 15, 2007; doi:10.1152/ajpregu.00318.2006
0363-6119/07 $8.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
293/1/R78    most recent
00318.2006v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yin, J.
Right arrow Articles by Chen, J. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yin, J.
Right arrow Articles by Chen, J. D.

APPETITE, OBESITY, DIGESTION, AND METABOLISM

Inhibitory effects of intestinal electrical stimulation on food intake, weight loss and gastric emptying in rats

Jieyun Yin,1 Jing Zhang,1 and Jiande DZ Chen1,2

1Veterans Research and Education Foundation, VA Medical Center, Oklahoma City, Oklahoma; and 2Division of Gastroenterology, University of Texas Medical Branch, Galveston, Texas

The aim was to investigate the effects of intestinal electrical stimulation (IES) on food intake, body weight, and gastric emptying in rats. An experiment on food intake and weight change was performed in 22 rats on a control diet and 10 diet-induced obese (DIO) rats for 4 wk with IES or sham IES. The effect of IES on gastric emptying was performed in another 20 rats in the control group. We found that 1) in control rats, 4-wk IES resulted in a reduction of 18.2% in the total amount of food intake compared with sham-IES (P = 0.02); the rats treated with IES had a weight change of –1 ± 7.8g (P = 0.03), which was equivalent to a weight loss of 6.2% due to IES when adjusted for normal growing. 2) Acute IES delayed gastric emptying by 20% in the control rats (P < 0.01). 3) In the DIO rats, 1-wk IES with the same parameters as those used in the control rats resulted in a significant reduction in the total amount of food intake (126.6 ± 6.3 g vs. 116.9 ± 3.2 g, P < 0.01). More reduction in food intake was noted, and a significant weight change was also observed when stimulation energy was increased. 4) No adverse events were observed in any of the experiments. In conclusion, IES delays gastric emptying, reduces food intake, and decreases weight gain in control growing rats. These data suggest that it is worthy to explore therapeutic potentials of IES for obesity.

gastrointestinal motility; obesity; diet-induced obese rats; stimulation parameter; mechanism


Address for reprint requests and other correspondence: J. Chen, Division of Gastroenterology, Route 0632, 1108 The Strand, Rm. 221, Univ. of Texas Medical Branch, Galveston, TX 77555-0632 (e-mail: jianchen{at}utmb.edu)




This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
X. Zhao, J. Yin, J. Chen, G. Song, L. Wang, H. Zhu, D. Brining, and J. D. Z. Chen
Inhibitory effects and mechanisms of intestinal electrical stimulation on gastric tone, antral contractions, pyloric tone, and gastric emptying in dogs
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2009; 296(1): R36 - R42.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2007 by the American Physiological Society.