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ENVIRONMENTAL, EXERCISE AND RESPIRATORY PHYSIOLOGY

Myocardial perfusion during exercise in endurance-trained and untrained humans

¹Turku PET Centre, ²Department of Medicine, and ³Department of Clinical Physiology, University of Turku, Turku, and ⁴Neuromuscular Research Centre, University of Jyväskylä, Jyväskylä, Finland; and ⁵Department of Health Sciences, Mid Sweden University, Östersund, Sweden

Submitted 6 November 2006 ; accepted in final form 22 May 2007

Because of technical challenges very little is known about absolute myocardial perfusion in humans in vivo during physical exercise. In the present study we applied positron emission tomography (PET) in order to 1) investigate the effects of dynamic bicycle exercise on myocardial perfusion and 2) clarify the possible effects of endurance training on myocardial perfusion during exercise. Myocardial perfusion was measured in endurance-trained and healthy untrained subjects at rest and during absolutely the same (150 W) and relatively similar [70% maximal power output (W_max)] bicycle exercise intensities. On average, the absolute myocardial perfusion was 3.4-fold higher during 150 W (P < 0.001) and 4.9-fold higher during 70% W_max (P < 0.001) than at rest. At 150 W myocardial perfusion was 46% lower in endurance-trained than in untrained subjects (1.67 ± 0.45 vs. 3.00 ± 0.75 ml·g^–1·min^–1; P < 0.05), whereas during 70% W_max perfusion was not significantly different between groups (P = not significant). When myocardial perfusion was normalized with rate-pressure product, the results were similar. Thus, according to the present results, myocardial perfusion increases in parallel with the increase in working intensity and in myocardial work rate. Endurance training seems to affect myocardial blood flow pattern during submaximal exercise and leads to more efficient myocardial pump function.

myocardial blood flow; endurance training; positron emission tomography

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